Sulfacetamide

Sulfacetamide

Systematic (IUPAC) name
N-[(4-aminophenyl)sulfonyl]acetamide
Clinical data
Trade names	Bleph-10
AHFS/Drugs.com	monograph
MedlinePlus	a601114
Pregnancy cat.	?
Legal status	?
Pharmacokinetic data
Half-life	7 to 12.8 hours
Identifiers
CAS number	144-80-9 Y
ATC code	S01AB04
PubChem	CID 5320
DrugBank	APRD00452
ChemSpider	5129 Y
UNII	4965G3J0F5 Y
KEGG	D05947 Y
ChEMBL	CHEMBL455 Y
Chemical data
Formula	C8H10N2O3S
Mol. mass	214.243 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11) Y Key:SKIVFJLNDNKQPD-UHFFFAOYSA-N Y
Y(what is this?)  (verify)

Sulfacetamide is a sulfonamide antibiotic.

Uses

Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis.^[1] When combined with sulfur, it is sold under the brand names Plexion, Clenia, Prascion, and Avar, which contain 10% sulfacetamide and 5% sulfur.^{[2][3] [4][5]}

Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor^[6] and rosacea.^[7] It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis.^{[citation needed]} It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa.^{[citation needed]} Sulfacetamide has antibacterial activity and is used to control acne. Products containing sulfacetamide and sulfur (a keratolytic) are commonly promoted for the treatment of acne rosacea (rosacea with papules, pustules, or both). There are several prescription topical products containing sulfacetamide, such as foams, shampoos, cream and washes.

Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism.^[8]

Adverse effects

The most common side effects of sulfacetamide/sulfur combination products are local irritation and contact dermatitis. Sulfacetamide should not be used by individuals who have a sensitivity to sulfur or sulfa.

References

1. ^ Klaron medical facts from Drugs.com
2. ^ Avar Cream Facts and Comparisons at Drugs.com
3. ^ Plexion medical facts from Drugs.com
4. ^ http://www.walgreens.com/marketing/library/finddrug/druginfo1.html;jsessionid=PbrFt7xeQx07A7CTF6HcFA**.p_dotcom34?particularDrug=Prascion&id=645494
5. ^ Clenia Cream Official FDA information, side effects and uses
6. ^ Hull CA, Johnson SM (June 2004). "A double-blind comparative study of Sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor". Cutis 73 (6): 425–9. PMID 15224788. 
7. ^ Del Rosso JQ (January 2004). "Evaluating the role of topical therapies in the management of rosacea: focus on combination Sulfacetamide and sulfur formulations". Cutis 73 (1 Suppl): 29–33. PMID 14959943. 
8. ^ Mastrolorenzo A, Supuran CT (2000). "Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives". Met Based Drugs 7 (1): 49–54. doi:10.1155/MBD.2000.49. PMC 2365193. PMID 18475922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2365193. 

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This dermatologic drug article is a stub. You can help Wikipedia by expanding it.v · Categories: Sulfonamide antibiotics Anti-acne preparations Acetamides Antibiotic stubs Dermatologic drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно сделать НИР? Seattle Drip Coffee Company Brasserie Les Halles Look at other dictionaries: Sulfacetamide/sulfur — Combination of Sulfacetamide Sulfonamide antibacterial Sulfur Keratolytic Clinical data Licence data US FDA …   Wikipedia sulfacetamide sodium — [USP] the sodium salt monohydrate of sulfacetamide, applied topically to the conjunctiva in the treatment of sulfonamide responsive eye infections and to the skin in the treatment of acne vulgaris …   Medical dictionary sulfacetamide — An antibacterial agent of the sulfonamide group, primarily used topically; s. sodium has the same uses as s. and also is used locally for eye infections and for prevention of gonorrheal ophthalmia in newborn infants. SYN: N sulfanilylacetamide. * …   Medical dictionary sulfacetamide — sul·fa·cet·a·mide …   English syllables sulfacetamide — noun a topical sulfonamide (trade name Sulamyd) used to treat eye infections • Syn: ↑Sulamyd • Usage Domain: ↑trade name (for: ↑Sulamyd) • Hypernyms: ↑sulfa drug, ↑ …   Useful english dictionary SULFACET — Sulfacetamide (Medical » Physiology) …   Abbreviations dictionary Dapsone — Systematic (IUPAC) name 4 [(4 aminobenzene)sulfonyl]aniline …   Wikipedia Liste d'antibiotiques — Cette liste répertorie les antibiotiques. Formule chimique Nom Masse molaire Numéro CAS EINECS PubChem C8H12N2O3S acide 6 aminopenicillanique 216.25748 551 16 6 …   Wikipédia en Français Liste des antibiotiques — Liste d antibiotiques Cette liste répertorie les antibiotiques. Formule chimique Nom Masse molaire Numéro CAS EINECS PubChem S acide 6 aminopenicillanique 216.25748 551 16 6 …   Wikipédia en Français Aspirin — Asprin redirects here. For the author, see Robert Asprin. Aspirin …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”