Nifurtoinol

Nifurtoinol
Nifurtoinol
Systematic (IUPAC) name
3-(hydroxymethyl)-1-{[(1E)-(5-nitro-2-furyl)
methylene]amino}imidazolidine-2,4-dione
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Routes Oral
Pharmacokinetic data
Excretion Renal (40–50% within the first 12 hours)
Identifiers
CAS number 1088-92-2
ATC code J01XE02
PubChem CID 9571062
UNII 980688H13O YesY
KEGG D07243 YesY
Chemical data
Formula C9H8N4O6 
Mol. mass 268.183 g/mol
 YesY(what is this?)  (verify)

Nifurtoinol (rINN, trade name Urfadyn) is a nitrofuran-derivative antibiotic used in the treatment of urinary tract infections.

It is also known as "hydroxymethylnitrofurantoin".[1]

References

  1. ^ Stricker BH, Blok AP, Claas FH, Van Parys GE, Desmet VJ (1988). "Hepatic injury associated with the use of nitrofurans: a clinicopathological study of 52 reported cases". Hepatology 8 (3): 599–606. doi:10.1002/hep.1840080327. PMID 3371877. 
v · d · eAntibacterials: nucleic acid inhibitors (J01E, J01M)
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
2,4-Diaminopyrimidine (Trimethoprim#, Brodimoprim, Tetroxoprim, Iclaprim†)
Sulfonamides
(DHPS inhibitor)
Other/ungrouped
Combinations
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
1st g.
2nd g.
3rd g.
4th g.
Vet.
Related (DG)
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
Nitrofuran derivatives
Nitrofurantoin#  • Furazolidone‡  • Nifurtoinol
RNA synthesis

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)


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