Tosufloxacin

Tosufloxacin
Tosufloxacin
Systematic (IUPAC) name
7-(3-Aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 100490-36-6 YesY
ATC code None
PubChem CID 5517
UNII GHJ553KQPS N
KEGG D02317 YesY
ChEMBL CHEMBL273348 N
Chemical data
Formula C19H15F3N4O3 
Mol. mass 404.34 g/mol
 N(what is this?)  (verify)

Tosufloxacin is a fluoroquinolone antibiotic. It has a controversial safety profile in relation to other fluoroquinolones. It is associated with severe thrombocytopenia and nephritis, and hepatotoxicity.[1] It is sold in Japan under the brand name Ozex.

See also

  • Fluoroquinolone
  • Fluoroquinolone toxicity

References

  1. ^ Rubinstein, E. (2001). "History of quinolones and their side effects.". Chemotherapy 47 Suppl 3: 3–8; discussion 44–8. doi:10.1159/000057838. PMID 11549783. 
v · d · eAntibacterials: nucleic acid inhibitors (J01E, J01M)
Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)
2,4-Diaminopyrimidine (Trimethoprim#, Brodimoprim, Tetroxoprim, Iclaprim†)
Sulfonamides
(DHPS inhibitor)
Other/ungrouped
Combinations
Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)
1st g.
2nd g.
3rd g.
Balofloxacin • Grepafloxacin‡ • Levofloxacin • Pazufloxacin • Sparfloxacin‡ • Temafloxacin‡ • Tosufloxacin
4th g.
Vet.
Related (DG)
Anaerobic DNA
inhibitors
Nitro- imidazole derivatives
Nitrofuran derivatives
RNA synthesis

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)


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