Oxolinic acid

Oxolinic acid

Systematic (IUPAC) name
5-Ethyl- 8-oxo- 5,8-dihydro [1,3] dioxolo [4,5-g] quinoline- 7-carboxylic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	14698-29-4 Y
ATC code	J01MB05
PubChem	CID 4628
UNII	L0A22B22FT N
KEGG	D02301 N
ChEMBL	CHEMBL416755 N
Chemical data
Formula	C13H11NO5
Mol. mass	261.23 g/mol
N(what is this?)  acid (verify)

Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s^[1][2]. Dosages 12-20mg/kg orally administered for five to ten days. The antibiotic works by inhibiting the enzyme DNA gyrase. It also acts as a dopamine reuptake inhibitor and has stimulant effects in mice.^[3]

See also

• Amfonelic acid
• Fluoroquinolone

References

1. ^ JP Patent 49138244
2. ^ Gleckman R, Alvarez S, Joubert DW, Matthews SJ (August 1979). "Drug therapy reviews: oxolinic acid". American Journal of Hospital Pharmacy 36 (8): 1077–9. PMID 384788. 
3. ^ Garcia de Mateos-Verchere J, Vaugeois JM, Naudin B, Costentin J (December 1998). "Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor". European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology 8 (4): 255–9. doi:10.1016/S0924-977X(97)00083-7. PMID 9928913. http://linkinghub.elsevier.com/retrieve/pii/S0924-977X(97)00083-7. 

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