Mothers against decapentaplegic homolog 5

SMAD family member 5
Identifiers
Symbols	SMAD5; DKFZp781C1895; DKFZp781O1323; Dwfc; MADH5
External IDs	OMIM: 603110 MGI: 1328787 HomoloGene: 4313 GeneCards: SMAD5 Gene
Gene Ontology Molecular function • DNA binding • receptor signaling protein activity • ubiquitin protein ligase binding • transcription activator activity • ligand-dependent nuclear receptor activity • protein binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • transcription factor activity Cellular component • nucleoplasm • nucleus • cytosol • transcription factor complex • intracellular • integral to membrane • cytoplasm Biological process • signal transduction • regulation of transcription, DNA-dependent • BMP signaling pathway • positive regulation of osteoblast differentiation • erythrocyte differentiation • transforming growth factor beta receptor signaling pathway • germ cell development • osteoblast fate commitment • embryonic pattern specification • positive regulation of transcription from RNA polymerase II promoter • transcription • cardiac muscle contraction Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4090	17129
Ensembl	ENSG00000113658	ENSMUSG00000021540
UniProt	Q99717	P97454
RefSeq (mRNA)	NM_001001420	NM_001164041
RefSeq (protein)	NP_001001419	NP_001157513
Location (UCSC)	Chr 5: 135.5 – 135.55 Mb	Chr 13: 56.8 – 56.84 Mb
PubMed search	[1]	[2]

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a protein that in humans is encoded by the SAMD5 gene.^[1]

SMAD5, as its name describes, is a homolog of the Drosophila gene: "Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMP's). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of hematopoietic progenitor cells.

References

1. ^ Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996). "Mad-related genes in the human". Nat. Genet. 13 (3): 347–9. doi:10.1038/ng0796-347. PMID 8673135.