KLF12

Kruppel-like factor 12, also known as KLF12, is a human gene.cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = ]

PBB_Summary
section_title =
summary_text = Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: KLF12 Kruppel-like factor 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11278| accessdate = ]

ee also

* Kruppel-like factors

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Imhof A, Schuierer M, Werner O, "et al." |title=Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor. |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 194–204 |year= 1999 |pmid= 9858544 |doi=
*cite journal | author=Roth C, Schuierer M, Günther K, Buettner R |title=Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12). |journal=Genomics |volume=63 |issue= 3 |pages= 384–90 |year= 2000 |pmid= 10704285 |doi= 10.1006/geno.1999.6084
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Schuierer M, Hilger-Eversheim K, Dobner T, "et al." |title=Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 27944–9 |year= 2001 |pmid= 11373277 |doi= 10.1074/jbc.M100070200
*cite journal | author=Zhu CH, Huang Y, Broman MT, Domann FE |title=Expression of AP-2 alpha in SV40 immortalized human lung fibroblasts is associated with a distinct pattern of cytosine methylation in the AP-2 alpha promoter. |journal=Biochim. Biophys. Acta |volume=1519 |issue= 1-2 |pages= 85–91 |year= 2001 |pmid= 11406275 |doi=
*cite journal | author=Chen C, Brabham WW, Stultz BG, "et al." |title=Defining a common region of deletion at 13q21 in human cancers. |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 333–44 |year= 2001 |pmid= 11433524 |doi= 10.1002/gcc.1152
*cite journal | author=Rozenblum E, Vahteristo P, Sandberg T, "et al." |title=A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 111–21 |year= 2002 |pmid= 11935316 |doi= 10.1007/s00439-001-0646-6
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Suda S, Rai T, Sohara E, "et al." |title=Postnatal expression of KLF12 in the inner medullary collecting ducts of kidney and its trans-activation of UT-A1 urea transporter promoter. |journal=Biochem. Biophys. Res. Commun. |volume=344 |issue= 1 |pages= 246–52 |year= 2006 |pmid= 16615998 |doi= 10.1016/j.bbrc.2006.03.138

External links

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