V-rel reticuloendotheliosis viral oncogene homolog A (avian)

PDB rendering based on 1bft.
Symbols RELA; MGC131774; NFKB3; p65
External IDs OMIM164014 MGI103290 HomoloGene32064 GeneCards: RELA Gene
RNA expression pattern
PBB GE RELA 201783 s at tn.png
PBB GE RELA 209878 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5970 19697
Ensembl ENSG00000173039 ENSMUSG00000024927
UniProt Q04206 Q3U3Q8
RefSeq (mRNA) NM_001145138.1 NM_009045.4
RefSeq (protein) NP_001138610.1 NP_033071.1
Location (UCSC) Chr 11:
65.42 – 65.43 Mb
Chr 19:
5.64 – 5.65 Mb
PubMed search [1] [2]

Transcription factor p65 is a protein that in humans is encoded by the RELA gene.[1]

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NF-κB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NF-κB. The NF-κB complex is inhibited by IκB (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-κB complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM][2]



RELA has been shown to interact with NFKBIB,[3][4] ETHE1,[5] NFKBIE,[6] RFC1,[7] TRIB3,[8] CREB binding protein,[9][10][11][12][13] Neutrophil cytosolic factor 1,[14] Glucocorticoid receptor,[15][16][17] MTPN,[18] BRCA1,[19] C-Fos,[20] POU2F1,[21] BTRC,[22] TATA-binding protein,[23][24] IκBα,[22][25][26][27][28][29][30] NFKB2,[31][32] NFKB1,[31][33] Nuclear receptor co-repressor 2,[34][35] Aryl hydrocarbon receptor,[36][37] CEBPB,[38][39] HDAC3,[25] DHX9,[40] PARP1,[41] ASCC3,[42] HDAC1,[10][26][43] CSNK2A2,[44] Histone deacetylase 2,[26][45] Casein kinase 2, alpha 1,[44] Protein kinase Mζ,[46] STAT3,[47] RNF25,[48] Sp1 transcription factor,[49][50] CDK9,[51] TAF4B,[52] MEN1,[53] PPP1R13L,[54][55] APBA2,[56] REL,[28][31][57] ING4,[58] EP300,[13][26] FUS,[59] PIAS3[9] and C-jun.[20]


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Further reading

  • Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights.". Annu. Rev. Immunol. 14: 649–83. doi:10.1146/annurev.immunol.14.1.649. PMID 8717528. 
  • Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204–11. PMID 11980335. 
  • Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development.". Leukemia 16 (6): 1053–68. doi:10.1038/sj.leu.2402482. PMID 12040437. 
  • Clarke R, Liu MC, Bouker KB, et al. (2003). "Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.". Oncogene 22 (47): 7316–39. doi:10.1038/sj.onc.1206937. PMID 14576841. 

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  • RELA — est l abréviation de Ikatan Relawan Rakyat Malaysia (volontaires malaisiens). Le corps des Rela est un des corps de volontaires civils créés par le gouvernement malaisien. Leur devoir principal est de vérifier les documents et les autorisations d …   Wikipédia en Français

  • Rela — est l abréviation de Ikatan Relawan Rakyat Malaysia (volontaires malaisiens). Le corps des Rela est un des corps de volontaires civils créés par le gouvernement malaisien. Leur devoir principal est de vérifier les documents et les autorisations d …   Wikipédia en Français

  • RELA — Обозначения Символы RELA; p65, NFKB3 Entrez Gene …   Википедия

  • rela — |é| s. f. 1. Armadilha para apanhar pássaros. 2.  [Zoologia] Espécie de rã que vive nas moitas. 3.  [Portugal: Beira] Pessoa impertinente. 4.  [Entomologia] Inseto (ralo). 5. Instrumento feito de uma haste e uma roda dentada, sobre a qual gira… …   Dicionário da Língua Portuguesa

  • RELA — Factor de transcripción p65 Estructura tridimensional de la proteína RELA. HUGO 9955 …   Wikipedia Español

  • RELA — abbr. Regional Railways South Wales & West, Laira [railway pool code] …   Dictionary of abbreviations

  • RELA Corps — RELA is the acronym of Ikatan Relawan Rakyat Malaysia (in English: Volunteers of Malaysian People). Rela Corps is a civil volunteer corps formed by the Malaysian government. Their main duty is to check the traveling documents and immigration… …   Wikipedia

  • Mohammed Rela — Mohamed Rela Born Mayiladuthurai, Tamil Nadu, India Citizenship Indian …   Wikipedia

  • relative — rel·a·tive || relÉ™tɪv n. family member, kinsman adj. proportionate, comparative; connected, associated; only gaining significance through a relationship to something else …   English contemporary dictionary

  • relativeness — rel·a·tive·ness || relÉ™tɪvnɪs n. quality of being relative …   English contemporary dictionary

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