GATA2

GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.cite journal | author = Lee ME, Temizer DH, Clifford JA, Quertermous T | title = Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells | journal = J. Biol. Chem. | volume = 266 | issue = 24 | pages = 16188–92 | year = 1991 | month = August | pmid = 1714909 | url = http://www.jbc.org/cgi/content/abstract/266/24/16188 | issn = ]

The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells.cite journal | author = Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW, Orkin SH | title = An early haematopoietic defect in mice lacking the transcription factor GATA-2 | journal = Nature | volume = 371 | issue = 6494 | pages = 221–6 | year = 1994 | month = September | pmid = 8078582 | doi = 10.1038/371221a0 | url = | issn = ] GATA1 is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation.cite journal | author = Briegel K, Lim KC, Plank C, Beug H, Engel JD, Zenke M | title = Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner | journal = Genes Dev. | volume = 7 | issue = 6 | pages = 1097–109 | year = 1993 | month = June | pmid = 8504932 | doi = 10.1101/gad.7.6.1097 | url = | issn = ] GATA3 expression is restricted to T-lymphoid cells and some nonhematopoietic cell types, including embryonic stem cells.cite web | title = Entrez Gene: GATA2 GATA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2624| accessdate = ]

ee also

* GATA transcription factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Minegishi N |title= [Transcription factors regulating hematopoiesis: researches spanning from molecule to whole body] |journal=Seikagaku |volume=74 |issue= 5 |pages= 398–402 |year= 2002 |pmid= 12073612 |doi=
*cite journal | author=Ohneda K, Yamamoto M |title=Roles of hematopoietic transcription factors GATA-1 and GATA-2 in the development of red blood cell lineage. |journal=Acta Haematol. |volume=108 |issue= 4 |pages= 237–45 |year= 2003 |pmid= 12432220 |doi=
*cite journal | author=Dorfman DM, Wilson DB, Bruns GA, Orkin SH |title=Human transcription factor GATA-2. Evidence for regulation of preproendothelin-1 gene expression in endothelial cells. |journal=J. Biol. Chem. |volume=267 |issue= 2 |pages= 1279–85 |year= 1992 |pmid= 1370462 |doi=
*cite journal | author=Page RL, Wharton JM, Wilkinson WE, "et al." |title=Bidisomide (SC-40230), a new antiarrhythmic agent: initial study of tolerability and pharmacokinetics. |journal=Clin. Pharmacol. Ther. |volume=51 |issue= 4 |pages= 371–8 |year= 1992 |pmid= 1563207 |doi=
*cite journal | author=Lee ME, Temizer DH, Clifford JA, Quertermous T |title=Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. |journal=J. Biol. Chem. |volume=266 |issue= 24 |pages= 16188–92 |year= 1991 |pmid= 1714909 |doi=
*cite journal | author=Zhang R, Min W, Sessa WC |title=Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15320–6 |year= 1995 |pmid= 7541039 |doi=
*cite journal | author=Osada H, Grutz G, Axelson H, "et al." |title=Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 21 |pages= 9585–9 |year= 1995 |pmid= 7568177 |doi=
*cite journal | author=Towatari M, May GE, Marais R, "et al." |title=Regulation of GATA-2 phosphorylation by mitogen-activated protein kinase and interleukin-3. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 4101–7 |year= 1995 |pmid= 7876160 |doi=
*cite journal | author=Tsai FY, Keller G, Kuo FC, "et al." |title=An early haematopoietic defect in mice lacking the transcription factor GATA-2. |journal=Nature |volume=371 |issue= 6494 |pages= 221–6 |year= 1994 |pmid= 8078582 |doi= 10.1038/371221a0
*cite journal | author=Briegel K, Lim KC, Plank C, "et al." |title=Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. |journal=Genes Dev. |volume=7 |issue= 6 |pages= 1097–109 |year= 1993 |pmid= 8504932 |doi=
*cite journal | author=Towatari M, Kanei Y, Saito H, Hamaguchi M |title=Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 long terminal repeat. |journal=AIDS |volume=12 |issue= 3 |pages= 253–9 |year= 1998 |pmid= 9517987 |doi=
*cite journal | author=Dasen JS, O'Connell SM, Flynn SE, "et al." |title=Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. |journal=Cell |volume=97 |issue= 5 |pages= 587–98 |year= 1999 |pmid= 10367888 |doi=
*cite journal | author=Zhang P, Behre G, Pan J, "et al." |title=Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 15 |pages= 8705–10 |year= 1999 |pmid= 10411939 |doi=
*cite journal | author=Wieser R, Volz A, Vinatzer U, "et al." |title=Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 239–45 |year= 2000 |pmid= 10873593 |doi= 10.1006/bbrc.2000.2947
*cite journal | author=Tsuzuki S, Towatari M, Saito H, Enver T |title=Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6276–86 |year= 2000 |pmid= 10938104 |doi=
*cite journal | author=Yamashita K, Discher DJ, Hu J, "et al." |title=Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12645–53 |year= 2001 |pmid= 11278891 |doi= 10.1074/jbc.M011344200
*cite journal | author=Ozawa Y, Towatari M, Tsuzuki S, "et al." |title=Histone deacetylase 3 associates with and represses the transcription factor GATA-2. |journal=Blood |volume=98 |issue= 7 |pages= 2116–23 |year= 2001 |pmid= 11567998 |doi=
*cite journal | author=Zhang SB, He QY, Zhao H, "et al." |title=Function of GATA transcription factors in hydroxyurea-induced HEL cells. |journal=Cell Res. |volume=11 |issue= 4 |pages= 301–10 |year= 2002 |pmid= 11787775 |doi= 10.1038/sj.cr.7290100
*cite journal | author=Tsuzuki S, Enver T |title=Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein. |journal=Blood |volume=99 |issue= 9 |pages= 3404–10 |year= 2002 |pmid= 11964310 |doi=
*cite journal | author=Hirasawa R, Shimizu R, Takahashi S, "et al." |title=Essential and instructive roles of GATA factors in eosinophil development. |journal=J. Exp. Med. |volume=195 |issue= 11 |pages= 1379–86 |year= 2002 |pmid= 12045236 |doi=

External links

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