TOX3

protein
Name = TOX high mobility group box family member 3
caption =


width =
HGNCid = 11972
Symbol = TOX3
AltSymbols = TNRC9, CAGF9
EntrezGene = 27324
OMIM = 611416
RefSeq = XM_049037
UniProt = O15405
PDB =
ECnumber =
Chromosome = 16
Arm = q
Band = 12.1
LocusSupplementaryData =

TOX high mobility group box family member 3, also known as TOX3, is a human gene.cite web | title = Entrez Gene: TOX high mobility group box family member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27324 | accessdate = ] cite journal | author = O'Flaherty E, Kaye J | title = TOX defines a conserved subfamily of HMG-box proteins | journal = BMC Genomics | volume = 4 | issue = 1 | pages = 13 | year = 2003 | month = April | pmid = 12697058 | pmc = 155677 | doi = | url = http://www.biomedcentral.com/1471-2164/4/13 | issn = ]

The protein encoded by this gene is a member of a subfamily of transcription factors that also includes TOX, TOX2, and TOX4 that share almost identical HMG-box DNA-binding domains which function to modify chromatin structure.

Disease linkage

Mutations in the TOX3 gene are associated with an increased risk of breast cancer.cite journal | author = Smid M, Wang Y, Klijn JG, Sieuwerts AM, Zhang Y, Atkins D, Martens JW, Foekens JA | title = Genes associated with breast cancer metastatic to bone | journal = J. Clin. Oncol. | volume = 24 | issue = 15 | pages = 2261–7 | year = 2006 | month = May | pmid = 16636340 | doi = 10.1200/JCO.2005.03.8802 | url = | issn = ] [cite journal |author=Easton DF, Pooley KA, Dunning AM, "et al" |title=Genome-wide association study identifies novel breast cancer susceptibility loci |journal=Nature |volume=447 |issue=7148 |pages=1087–93 |year=2007 |month=Jun |pmid=17529967 |doi=10.1038/nature05887 |url=] [cite journal |author=Stacey SN, Manolescu A, Sulem P, "et al" |title=Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer |journal=Nat. Genet. |volume=39 |issue=7 |pages=865–9 |year=2007 |month=Jul |pmid=17529974 |doi=10.1038/ng2064 |url=] cite journal | author = Antoniou AC, Spurdle AB, Sinilnikova OM, "et al" | title = Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers | journal = Am. J. Hum. Genet. | volume = 82 | issue = 4 | pages = 937–48 | year = 2008 | month = April | pmid = 18355772 | doi = 10.1016/j.ajhg.2008.02.008 | url = | issn = ]

References