ZNF423

Zinc finger protein 423, also known as ZNF423, is a human gene.cite web | title = Entrez Gene: ZNF423 zinc finger protein 423| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23090| accessdate = ]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.

References

Further reading

*cite journal | author=Warming S, Rachel RA, Jenkins NA, Copeland NG. |title=Zfp423 is required for normal cerebellar development. |journal=Mol Cell Biol. |volume=26 |issue= 18 |pages= 6913-22. |year= 2006 |pmid= 16943432
*cite journal | author=Alcaraz WA, Gold DA, Raponi E, "et al." |title=Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation. |journal=Proc Natl Acad Sci U S A. |volume=103 |issue= 51 |pages= 19424-9. |year= 2006 |pmid= 17151198
*cite journal | author=Cheng LE, Reed RR. |title=Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis. |journal=Neuron |volume=54 |issue= 4 |pages= 547-57. |year= 2007 |pmid= 17521568
*cite journal | author=Cheng LE, Zhang J, Reed RR |title=The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. |journal=Dev Biol. |volume=307 |issue= 1 |pages= 43–52 |year= 2007 |pmid= 17524391 |doi= 10.1016/j.ydbio.2007.04.005 PBB_Further_reading
citations =
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Ku MC, Stewart S, Hata A |title=Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 3 |pages= 702–7 |year= 2004 |pmid= 14623329 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shim S, Bae N, Han JK |title=Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ). |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3107–17 |year= 2002 |pmid= 12136093 |doi=
*cite journal | author=Hata A, Seoane J, Lagna G, "et al." |title=OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. |journal=Cell |volume=100 |issue= 2 |pages= 229–40 |year= 2000 |pmid= 10660046 |doi=
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=
*cite journal | author=Tsai RY, Reed RR |title=Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. |journal=J. Neurosci. |volume=17 |issue= 11 |pages= 4159–69 |year= 1997 |pmid= 9151733 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457

External links

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