Testicular receptor 2

Nuclear receptor subfamily 2, group C, member 1
Identifiers
Symbols	NR2C1; TR2; TR2-11
External IDs	OMIM: 601529 MGI: 1352465 HomoloGene: 55731 IUPHAR: NR2C1 GeneCards: NR2C1 Gene
Gene Ontology Molecular function • DNA binding • sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • receptor activity • zinc ion binding • protein homodimerization activity • histone deacetylase binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleus • nucleoplasm • PML body Biological process • negative regulation of transcription from RNA polymerase II promoter • gene expression • regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor • steroid hormone mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7181	22025
Ensembl	ENSG00000120798	ENSMUSG00000005897
UniProt	P13056	Q0VGP8
RefSeq (mRNA)	NM_001032287.2	NM_011629.3
RefSeq (protein)	NP_001027458.1	NP_035759.3
Location (UCSC)	Chr 12: 95.41 – 95.47 Mb	Chr 10: 93.61 – 93.66 Mb
PubMed search	[1]	[2]

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.^[1][2] TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

• Androgen receptor,^[3]
• Estrogen receptor alpha,^[4]
• HDAC3,^[5][6][7] and
• HDAC4.^[6][7]

See also

• Testicular receptor

References

1. ^ "Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181. 
2. ^ Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (December 1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochem. Biophys. Res. Commun. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158. 
3. ^ Mu X, Chang C (October 2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". Prostate 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. 
4. ^ Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C (September 2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". J. Biol. Chem. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804. 
5. ^ Li G, Franco PJ, Wei LN (October 2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochem. Biophys. Res. Commun. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922. 
6. ^ ^{a b} Franco PJ, Li G, Wei LN (August 2003). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Mol. Cell. Endocrinol. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. 
7. ^ ^{a b} Franco PJ, Farooqui M, Seto E, Wei LN (August 2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol. 15 (8): 1318–28. doi:10.1210/me.15.8.1318. PMID 11463856. 

Further reading

• Chang C, Kokontis J (1988). "Identification of a new member of the steroid receptor super-family by cloning and sequence analysis". Biochem. Biophys. Res. Commun. 155 (2): 971–7. doi:10.1016/S0006-291X(88)80591-6. PMID 3421977. 
• Lin DL, Wu SQ, Chang C (1998). "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily". Endocrine 8 (2): 123–34. doi:10.1385/ENDO:8:2:123. PMID 9704569. 
• Lee CH, Chinpaisal C, Wei LN (1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". J. Biol. Chem. 273 (39): 25209–15. doi:10.1074/jbc.273.39.25209. PMID 9737983. 
• Lee CH, Chinpaisal C, Wei LN (1998). "Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2". Mol. Cell. Biol. 18 (11): 6745–55. PMC 109258. PMID 9774688. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109258. 
• Yu Z, Lee CH, Chinpaisal C, Wei LN (1999). "A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2". J. Endocrinol. 159 (1): 53–60. doi:10.1677/joe.0.1590053. PMID 9795341. 
• Franco PJ, Farooqui M, Seto E, Wei LN (2001). "The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases". Mol. Endocrinol. 15 (8): 1318–28. doi:10.1210/me.15.8.1318. PMID 11463856. 
• Tanabe O, Katsuoka F, Campbell AD et al. (2002). "An embryonic/fetal β-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". EMBO J. 21 (13): 3434–42. doi:10.1093/emboj/cdf340. PMC 126089. PMID 12093744. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126089. 
• Hu YC, Shyr CR, Che W et al. (2002). "Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor". J. Biol. Chem. 277 (37): 33571–9. doi:10.1074/jbc.M203531200. PMID 12093804. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Inui S, Lee YF, Chang E et al. (2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". J. Dermatol. Sci. 31 (1): 65–71. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366. 
• Franco PJ, Li G, Wei LN (2004). "Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase". Mol. Cell. Endocrinol. 206 (1–2): 1–12. doi:10.1016/S0303-7207(03)00254-5. PMID 12943985. 
• Mu X, Chang C (2003). "TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3". Prostate 57 (2): 129–33. doi:10.1002/pros.10282. PMID 12949936. 
• Li G, Franco PJ, Wei LN (2003). "Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2". Biochem. Biophys. Res. Commun. 310 (2): 384–90. doi:10.1016/j.bbrc.2003.08.145. PMID 14521922. 
• Lin YL, Wang YH, Lee HJ (2006). "Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A". Biochem. Biophys. Res. Commun. 350 (2): 430–6. doi:10.1016/j.bbrc.2006.09.061. PMID 17010934.