Retinoid X receptor

Retinoid X receptor

protein
Name = retinoid X receptor alpha
caption =


width =
HGNCid = 10477
Symbol = RXRA
AltSymbols =
EntrezGene = 6256
OMIM = 180245
RefSeq = NM_002957
UniProt = P19793
PDB =
ECnumber =
Chromosome = 9
Arm = q
Band = 34
LocusSupplementaryData = protein
Name = retinoid X receptor beta
caption =


width =
HGNCid = 10478
Symbol = RXRB
AltSymbols =
EntrezGene = 6257
OMIM = 180246
RefSeq = NM_021976
UniProt = P28702
PDB =
ECnumber =
Chromosome = 6
Arm = p
Band = 21.3
LocusSupplementaryData = protein
Name = retinoid X receptor gamma
caption =


width =
HGNCid = 10479
Symbol = RXRG
AltSymbols =
EntrezGene = 6258
OMIM = 180247
RefSeq = NM_006917
UniProt = P48443
PDB =
ECnumber =
Chromosome = 1
Arm = q
Band = 22
LocusSupplementaryData = -q23

The retinoid X receptor (RXR)cite journal |author=Germain P, Chambon P, Eichele G, Evans RM, Lazar MA, Leid M, De Lera AR, Lotan R, Mangelsdorf DJ, Gronemeyer H|title=International Union of Pharmacology. LXIII. Retinoid X receptors |journal= Pharmacol Rev |volume= 58 |issue= 4 |pages= 760–72 |year= 2006| doi = 10.1124/pr.58.4.7 |pmid= 17132853] is a type of nuclear receptor which is activated by 9-cis retinoic acid.cite journal |author=Allenby G, Bocquel MT, Saunders M, Kazmer S, Speck J, Rosenberger M, Lovey A, Kastner P, Grippo JF, Chambon P, Levin AA|title=Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids |journal= Proc Natl Acad Sci U S A |volume= 90 |issue= 1 |pages= 30–4 |year= 1993| doi = 10.1073/pnas.90.1.30 |pmid= 8380496] There are three retinoic acid receptors (RXR), RXR-alpha, RXR-beta, and RXR-gamma encoded by the gene|RXRA, gene|RXRB, gene|RXRG genes respectively.

RXR heterodimerizes with nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR.

As with other type II nuclear receptors, the RXR heterodimer in the absence of ligand is bound to hormone response elements complexed with corepressor protein. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein.

ee also

* Retinoic acid receptor
* Retinoid X receptor alpha
* Retinoid X receptor beta
* Retinoid X receptor gamma

References

External links

*


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