Retinoid X receptor gamma

Retinoid X receptor, gamma
Crystallographic structure of the DNA-binding domain of the Retinoid X receptor, gamma. PDB rendering based on 1by4.
Available structures PDB 1by4, 1dsz, 1r0n, 1rxr, 2gl8, 2nll
Identifiers
Symbols	RXRG; NR2B3; RXRC
External IDs	OMIM: 180247 MGI: 98216 HomoloGene: 21373 IUPHAR: NR2B3 GeneCards: RXRG Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • retinoid-X receptor activity • steroid binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleus • nucleoplasm Biological process • peripheral nervous system development • heart development • skeletal muscle tissue development • gene expression • response to organic cyclic compound • neuron differentiation • response to retinoic acid • cellular response to hormone stimulus • regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor • positive regulation of transcription from RNA polymerase II promoter • retinoic acid receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6258	20183
Ensembl	ENSG00000143171	ENSMUSG00000015843
UniProt	P48443	Q3V193
RefSeq (mRNA)	NM_006917.4	NM_009107
RefSeq (protein)	NP_001009598	NP_033133
Location (UCSC)	Chr 1: 165.37 – 165.41 Mb	Chr 1: 169.53 – 169.57 Mb
PubMed search	[1]	[2]

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.^[1][2]

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[2]

See also

• Retinoid X receptor

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.^[3]

References

1. ^ Almasan A, Mangelsdorf DJ, Ong ES, Wahl GM, Evans RM (April 1994). "Chromosomal localization of the human retinoid X receptors". Genomics 20 (3): 397–403. doi:10.1006/geno.1994.1193. PMID 8034312. 
2. ^ ^{a b} "Entrez Gene: RXRG retinoid X receptor, gamma". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6258. 
3. ^ Li, D; Wang F, Samuels H H (Dec. 2001). "Domain structure of the NRIF3 family of coregulators suggests potential dual roles in transcriptional regulation". Mol. Cell. Biol. (United States) 21 (24): 8371–84. doi:10.1128/MCB.21.24.8371-8384.2001. ISSN 0270-7306. PMC 100002. PMID 11713274. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100002. 

Further reading

• Szanto A, Narkar V, Shen Q, et al. (2005). "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2: S126–43. doi:10.1038/sj.cdd.4401533. PMID 15608692. 
• Leid M, Kastner P, Lyons R, et al. (1992). "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. 
• Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. (1992). "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.". Genes Dev. 6 (3): 329–44. doi:10.1101/gad.6.3.329. PMID 1312497. 
• Nagata T, Weiss EH, Abe K, et al. (1995). "Physical mapping of the retinoid X receptor B gene in mouse and human.". Immunogenetics 41 (2–3): 83–90. doi:10.1007/BF00182317. PMID 7806300. 
• Muscat GE, Mynett-Johnson L, Dowhan D, et al. (1994). "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. doi:10.1093/nar/22.4.583. PMC 307847. PMID 8127707. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=307847. 
• Kamei Y, Xu L, Heinzel T, et al. (1996). "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell 85 (3): 403–14. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895. 
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Sanno N, Sugawara A, Teramoto A, et al. (1997). "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology 65 (4): 299–306. doi:10.1159/000127188. PMID 9143002. 
• Reichrath J, Mittmann M, Kamradt J, Müller SM (1997). "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. doi:10.1023/A:1026481205135. PMID 9147069. 
• Xu XC, Sozzi G, Lee JS, et al. (1997). "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. doi:10.1093/jnci/89.9.624. PMID 9150186. 
• Yusta B, Alarid ET, Gordon DF, et al. (1998). "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology 139 (11): 4476–82. doi:10.1210/en.139.11.4476. PMID 9794455. 
• Ito K, Suzuki T, Moriya T, et al. (2001). "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. doi:10.1210/jc.86.6.2721. PMID 11397877. 
• Kim SW, Kim HJ, Jung DJ, et al. (2001). "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene 20 (45): 6638–42. doi:10.1038/sj.onc.1204695. PMID 11641790. 
• Brabender J, Danenberg KD, Metzger R, et al. (2002). "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. PMID 11839661. 
• Wansa KD, Harris JM, Muscat GE (2002). "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. doi:10.1074/jbc.M203572200. PMID 12082103. 
• Wang Q, Fujii H, Knipp GT (2003). "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta 23 (8–9): 661–71. doi:10.1053/plac.2002.0855. PMID 12361685. 
• Kimura Y, Suzuki T, Kaneko C, et al. (2003). "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. PMID 12444914. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Alfaro JM, Fraile B, Lobo MV, et al. (2003). "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. PMID 12514092. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.