E2F3

E2F transcription factor 3, also known as E2F3, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Alternative gene splicing is found in the mouse homolog, but has not reported in human yet.cite web | title = Entrez Gene: E2F3 E2F transcription factor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1871| accessdate = ]

ee also

* E2F

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=Wu CL, Zukerberg LR, Ngwu C, "et al." |title=In vivo association of E2F and DP family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2536–46 |year= 1995 |pmid= 7739537 |doi=
*cite journal | author=Lees JA, Saito M, Vidal M, "et al." |title=The retinoblastoma protein binds to a family of E2F transcription factors. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7813–25 |year= 1994 |pmid= 8246996 |doi=
*cite journal | author=Karlseder J, Rotheneder H, Wintersberger E |title=Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1659–67 |year= 1996 |pmid= 8657141 |doi=
*cite journal | author=Rogers KT, Higgins PD, Milla MM, "et al." |title=DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7594–9 |year= 1996 |pmid= 8755520 |doi=
*cite journal | author=Magae J, Wu CL, Illenye S, "et al." |title=Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. |journal=J. Cell. Sci. |volume=109 ( Pt 7) |issue= |pages= 1717–26 |year= 1997 |pmid= 8832394 |doi=
*cite journal | author=Hofmann F, Livingston DM |title=Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. |journal=Genes Dev. |volume=10 |issue= 7 |pages= 851–61 |year= 1996 |pmid= 8846921 |doi=
*cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095–100 |year= 1997 |pmid= 9144196 |doi=
*cite journal | author=Dynlacht BD, Moberg K, Lees JA, "et al." |title=Specific regulation of E2F family members by cyclin-dependent kinases. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3867–75 |year= 1997 |pmid= 9199321 |doi=
*cite journal | author=Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG |title=Differential activities of E2F family members: unique functions in regulating transcription. |journal=Mol. Carcinog. |volume=22 |issue= 3 |pages= 190–8 |year= 1998 |pmid= 9688145 |doi=
*cite journal | author=Humbert PO, Verona R, Trimarchi JM, "et al." |title=E2f3 is critical for normal cellular proliferation. |journal=Genes Dev. |volume=14 |issue= 6 |pages= 690–703 |year= 2000 |pmid= 10733529 |doi=
*cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804–16 |year= 2000 |pmid= 10766737 |doi=
*cite journal | author=Leone G, Nuckolls F, Ishida S, "et al." |title=Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3626–32 |year= 2000 |pmid= 10779352 |doi=
*cite journal | author=He Y, Armanious MK, Thomas MJ, Cress WD |title=Identification of E2F-3B, an alternative form of E2F-3 lacking a conserved N-terminal region. |journal=Oncogene |volume=19 |issue= 30 |pages= 3422–33 |year= 2000 |pmid= 10918599 |doi= 10.1038/sj.onc.1203682
*cite journal | author=Yamochi T, Semba K, Tsuji K, "et al." |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076–82 |year= 2002 |pmid= 11733001 |doi=
*cite journal | author=Weinmann AS, Yan PS, Oberley MJ, "et al." |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235–44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102
*cite journal | author=Ren B, Cam H, Takahashi Y, "et al." |title=E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 245–56 |year= 2002 |pmid= 11799067 |doi= 10.1101/gad.949802
*cite journal | author=He Y, Cress WD |title=E2F-3B is a physiological target of cyclin A. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23493–9 |year= 2002 |pmid= 11980909 |doi= 10.1074/jbc.M202629200
*cite journal | author=Schlisio S, Halperin T, Vidal M, Nevins JR |title=Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. |journal=EMBO J. |volume=21 |issue= 21 |pages= 5775–86 |year= 2002 |pmid= 12411495 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

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