E2F2

E2F transcription factor 2, also known as E2F2, is a human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.cite web | title = Entrez Gene: E2F2 E2F transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1870| accessdate = ]

ee also

* E2F

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dyson N |title=The regulation of E2F by pRB-family proteins. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2245–62 |year= 1998 |pmid= 9694791 |doi=
*cite journal | author=Wu CL, Zukerberg LR, Ngwu C, "et al." |title=In vivo association of E2F and DP family proteins. |journal=Mol. Cell. Biol. |volume=15 |issue= 5 |pages= 2536–46 |year= 1995 |pmid= 7739537 |doi=
*cite journal | author=Ivey-Hoyle M, Conroy R, Huber HE, "et al." |title=Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7802–12 |year= 1994 |pmid= 8246995 |doi=
*cite journal | author=Lees JA, Saito M, Vidal M, "et al." |title=The retinoblastoma protein binds to a family of E2F transcription factors. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7813–25 |year= 1994 |pmid= 8246996 |doi=
*cite journal | author=Karlseder J, Rotheneder H, Wintersberger E |title=Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1659–67 |year= 1996 |pmid= 8657141 |doi=
*cite journal | author=Lin SY, Black AR, Kostic D, "et al." |title=Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. |journal=Mol. Cell. Biol. |volume=16 |issue= 4 |pages= 1668–75 |year= 1996 |pmid= 8657142 |doi=
*cite journal | author=Rogers KT, Higgins PD, Milla MM, "et al." |title=DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 15 |pages= 7594–9 |year= 1996 |pmid= 8755520 |doi=
*cite journal | author=Magae J, Wu CL, Illenye S, "et al." |title=Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. |journal=J. Cell. Sci. |volume=109 ( Pt 7) |issue= |pages= 1717–26 |year= 1997 |pmid= 8832394 |doi=
*cite journal | author=Hofmann F, Livingston DM |title=Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. |journal=Genes Dev. |volume=10 |issue= 7 |pages= 851–61 |year= 1996 |pmid= 8846921 |doi=
*cite journal | author=Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D |title=The subcellular localization of E2F-4 is cell-cycle dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 10 |pages= 5095–100 |year= 1997 |pmid= 9144196 |doi=
*cite journal | author=Pierce AM, Schneider-Broussard R, Philhower JL, Johnson DG |title=Differential activities of E2F family members: unique functions in regulating transcription. |journal=Mol. Carcinog. |volume=22 |issue= 3 |pages= 190–8 |year= 1998 |pmid= 9688145 |doi=
*cite journal | author=Halaban R, Cheng E, Smicun Y, Germino J |title=Deregulated E2F transcriptional activity in autonomously growing melanoma cells. |journal=J. Exp. Med. |volume=191 |issue= 6 |pages= 1005–16 |year= 2000 |pmid= 10727462 |doi=
*cite journal | author=Takahashi Y, Rayman JB, Dynlacht BD |title=Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. |journal=Genes Dev. |volume=14 |issue= 7 |pages= 804–16 |year= 2000 |pmid= 10766737 |doi=
*cite journal | author=Denis GV, Vaziri C, Guo N, Faller DV |title=RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F. |journal=Cell Growth Differ. |volume=11 |issue= 8 |pages= 417–24 |year= 2001 |pmid= 10965846 |doi=
*cite journal | author=Wu L, Timmers C, Maiti B, "et al." |title=The E2F1-3 transcription factors are essential for cellular proliferation. |journal=Nature |volume=414 |issue= 6862 |pages= 457–62 |year= 2001 |pmid= 11719808 |doi= 10.1038/35106593
*cite journal | author=Yamochi T, Semba K, Tsuji K, "et al." |title=ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3). |journal=Eur. J. Biochem. |volume=268 |issue= 23 |pages= 6076–82 |year= 2002 |pmid= 11733001 |doi=
*cite journal | author=Weinmann AS, Yan PS, Oberley MJ, "et al." |title=Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. |journal=Genes Dev. |volume=16 |issue= 2 |pages= 235–44 |year= 2002 |pmid= 11799066 |doi= 10.1101/gad.943102
*cite journal | author=Crowley TE, Kaine EM, Yoshida M, "et al." |title=Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein. |journal=Mol. Endocrinol. |volume=16 |issue= 8 |pages= 1727–37 |year= 2003 |pmid= 12145330 |doi=
*cite journal | author=Schlisio S, Halperin T, Vidal M, Nevins JR |title=Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. |journal=EMBO J. |volume=21 |issue= 21 |pages= 5775–86 |year= 2002 |pmid= 12411495 |doi=

External links

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