TBX2

T-box 2, also known as TBX2, is a human gene.cite web | title = Entrez Gene: TBX2 T-box 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6909| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.cite web | title = Entrez Gene: TBX2 T-box 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6909| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Campbell C, Goodrich K, Casey G, Beatty B |title=Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. |journal=Genomics |volume=28 |issue= 2 |pages= 255–60 |year= 1996 |pmid= 8530034 |doi= 10.1006/geno.1995.1139
*cite journal | author=Law DJ, Gebuhr T, Garvey N, "et al." |title=Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family. |journal=Mamm. Genome |volume=6 |issue= 11 |pages= 793–7 |year= 1996 |pmid= 8597636 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Campbell CE, Casey G, Goodrich K |title=Genomic structure of TBX2 indicates conservation with distantly related T-box genes. |journal=Mamm. Genome |volume=9 |issue= 1 |pages= 70–3 |year= 1998 |pmid= 9434949 |doi=
*cite journal | author=Carreira S, Dexter TJ, Yavuzer U, "et al." |title=Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5099–108 |year= 1998 |pmid= 9710594 |doi=
*cite journal | author=He M, Wen L, Campbell CE, "et al." |title=Transcription repression by Xenopus ET and its human ortholog TBX3, a gene involved in ulnar-mammary syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 18 |pages= 10212–7 |year= 1999 |pmid= 10468588 |doi=
*cite journal | author=Sinha S, Abraham S, Gronostajski RM, Campbell CE |title=Differential DNA binding and transcription modulation by three T-box proteins, T, TBX1 and TBX2. |journal=Gene |volume=258 |issue= 1-2 |pages= 15–29 |year= 2001 |pmid= 11111039 |doi=
*cite journal | author=Brummelkamp TR, Kortlever RM, Lingbeek M, "et al." |title=TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6567–72 |year= 2002 |pmid= 11748239 |doi= 10.1074/jbc.M110492200
*cite journal | author=Lingbeek ME, Jacobs JJ, van Lohuizen M |title=The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26120–7 |year= 2002 |pmid= 12000749 |doi= 10.1074/jbc.M200403200
*cite journal | author=Habets PE, Moorman AF, Clout DE, "et al." |title=Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. |journal=Genes Dev. |volume=16 |issue= 10 |pages= 1234–46 |year= 2002 |pmid= 12023302 |doi= 10.1101/gad.222902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Andelfinger G, Etter L, Dyment M, "et al." |title=Radiation hybrid mapping and genomic organization of canine TBX2 and TBX4. |journal=Anim. Genet. |volume=34 |issue= 4 |pages= 307–9 |year= 2004 |pmid= 12873224 |doi=
*cite journal | author=Borke JL, Yu JC, Isales CM, "et al." |title=Tension-induced reduction in connexin 43 expression in cranial sutures is linked to transcriptional regulation by TBX2. |journal=Annals of plastic surgery |volume=51 |issue= 5 |pages= 499–504 |year= 2004 |pmid= 14595187 |doi= 10.1097/01.SAP.0000067964.14122.3E
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vance KW, Carreira S, Brosch G, Goding CR |title=Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. |journal=Cancer Res. |volume=65 |issue= 6 |pages= 2260–8 |year= 2005 |pmid= 15781639 |doi= 10.1158/0008-5472.CAN-04-3045
*cite journal | author=Bilican B, Goding CR |title=Cell cycle regulation of the T-box transcription factor tbx2. |journal=Exp. Cell Res. |volume=312 |issue= 12 |pages= 2358–66 |year= 2006 |pmid= 16730707 |doi= 10.1016/j.yexcr.2006.03.033

External links

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