- FOXN1
Forkhead box N1, also known as FOXN1, is a human
gene .cite web | title = Entrez Gene: FOXN1 forkhead box N1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8456| accessdate = ]PBB_Summary
section_title =
summary_text = Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.cite web | title = Entrez Gene: FOXN1 forkhead box N1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8456| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Mecklenburg L, Tychsen B, Paus R |title=Learning from nudity: lessons from the nude phenotype. |journal=Exp. Dermatol. |volume=14 |issue= 11 |pages= 797–810 |year= 2006 |pmid= 16232301 |doi= 10.1111/j.1600-0625.2005.00362.x
*cite journal | author=Nehls M, Pfeifer D, Schorpp M, "et al." |title=New member of the winged-helix protein family disrupted in mouse and rat nude mutations. |journal=Nature |volume=372 |issue= 6501 |pages= 103–7 |year= 1994 |pmid= 7969402 |doi= 10.1038/372103a0
*cite journal | author=Schorpp M, Hofmann M, Dear TN, Boehm T |title=Characterization of mouse and human nude genes. |journal=Immunogenetics |volume=46 |issue= 6 |pages= 509–15 |year= 1997 |pmid= 9321431 |doi=
*cite journal | author=Frank J, Pignata C, Panteleyev AA, "et al." |title=Exposing the human nude phenotype. |journal=Nature |volume=398 |issue= 6727 |pages= 473–4 |year= 1999 |pmid= 10206641 |doi= 10.1038/18997
*cite journal | author=Gattenlöhner S, Müller-Hermelink HK, Marx A |title=Transcription of the nude gene (WHN) in human normal organs and mediastinal and pulmonary tumors. |journal=Pathol. Res. Pract. |volume=195 |issue= 8 |pages= 571–4 |year= 1999 |pmid= 10483588 |doi=
*cite journal | author=Schlake T, Schorpp M, Maul-Pavicic A, "et al." |title=Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. |journal=Dev. Dyn. |volume=217 |issue= 4 |pages= 368–76 |year= 2000 |pmid= 10767081 |doi= 10.1002/(SICI)1097-0177(200004)217:4<368::AID-DVDY4>3.0.CO;2-Z |doilabel=10.1002/(SICI)1097-0177(200004)217:4368::AID-DVDY43.0.CO;2-Z
*cite journal | author=Adriani M, Martinez-Mir A, Fusco F, "et al." |title=Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. |journal=Ann. Hum. Genet. |volume=68 |issue= Pt 3 |pages= 265–8 |year= 2004 |pmid= 15180707 |doi= 10.1046/j.1529-8817.2004.00091.x
*cite journal | author=Janes SM, Ofstad TA, Campbell DH, "et al." |title=Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt. |journal=J. Cell. Sci. |volume=117 |issue= Pt 18 |pages= 4157–68 |year= 2005 |pmid= 15316080 |doi= 10.1242/jcs.01302
*cite journal | author=Nonaka D, Henley JD, Chiriboga L, Yee H |title=Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. |journal=Am. J. Surg. Pathol. |volume=31 |issue= 7 |pages= 1038–44 |year= 2007 |pmid= 17592270 |doi= 10.1097/PAS.0b013e31802b4917
*cite journal | author=Weiner L, Han R, Scicchitano BM, "et al." |title=Dedicated epithelial recipient cells determine pigmentation patterns. |journal=Cell |volume=130 |issue= 5 |pages= 932–42 |year= 2007 |pmid= 17803914 |doi= 10.1016/j.cell.2007.07.024PBB_Controls
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