NKX2-2

NK2 homeobox 2
Identifiers
Symbols	NKX2-2; NKX2.2; NKX2B
External IDs	OMIM: 604612 MGI: 97347 HomoloGene: 1879 GeneCards: NKX2-2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • transcription factor binding • sequence-specific DNA binding Cellular component • nucleus • intracellular part Biological process • type B pancreatic cell development • pancreatic A cell fate commitment • type B pancreatic cell fate commitment • pancreatic PP cell fate commitment • smoothened signaling pathway • multicellular organismal development • nervous system development • brain development • oligodendrocyte development • spinal cord motor neuron differentiation • spinal cord oligodendrocyte cell fate specification • endocrine pancreas development • negative regulation of neuron differentiation • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • digestive tract development • neuron fate specification • astrocyte differentiation • positive regulation of oligodendrocyte differentiation • ventral spinal cord interneuron fate determination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4821	18088
Ensembl	ENSG00000125820	ENSMUSG00000027434
UniProt	O95096	Q3URZ4
RefSeq (mRNA)	NM_002509	XM_001004391
RefSeq (protein)	NP_002500	XP_001004391
Location (UCSC)	Chr 20: 21.49 – 21.49 Mb	Chr 2: 147 – 147.02 Mb
PubMed search	[1]	[2]

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.^[1][2][3]

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.^[3]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.^[4]

References

1. ^ Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Sep 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes 47 (8): 1356–8. doi:10.2337/diabetes.47.8.1356. PMID 9703340. 
2. ^ Price M, Lazzaro D, Pohl T, Mattei MG, Ruther U, Olivo JC, Duboule D, Di Lauro R (Mar 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron 8 (2): 241–55. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. 
3. ^ ^{a b} "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4821. 
4. ^ Tochitani S, Hayashizaki Y (August 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochem. Biophys. Res. Commun. 372 (4): 691–6. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132. 

External links

• http://atlasgeneticsoncology.org/Genes/NKX22ID44177ch20p11.html

Further reading

• Hessabi B, Schmidt I, Walther R (2000). "The homeodomain of Nkx2.2 carries two cooperatively acting nuclear localization signals.". Biochem. Biophys. Res. Commun. 270 (3): 695–700. doi:10.1006/bbrc.2000.2491. PMID 10772886. 
• Wang CC, Brodnicki T, Copeland NG, et al. (2000). "Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.". Mamm. Genome 11 (6): 466–8. doi:10.1007/s003350010089. PMID 10818213. 
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Sun T, Dong H, Wu L, et al. (2003). "Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex.". J. Neurosci. 23 (29): 9547–56. PMID 14573534. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Smith R, Owen LA, Trem DJ, et al. (2006). "Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma.". Cancer Cell 9 (5): 405–16. doi:10.1016/j.ccr.2006.04.004. PMID 16697960. 
• Pauls S, Zecchin E, Tiso N, et al. (2007). "Function and regulation of zebrafish nkx2.2a during development of pancreatic islet and ducts.". Dev. Biol. 304 (2): 875–90. doi:10.1016/j.ydbio.2007.01.024. PMID 17335795. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.