- ASCL1
Achaete-scute complex homolog 1 (Drosophila), also known as ASCL1, is a human
gene .cite web | title = Entrez Gene: ASCL1 achaete-scute complex homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=429| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. It is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests that it may also play a role in tumor formation.cite web | title = Entrez Gene: ASCL1 achaete-scute complex homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=429| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Chen H, Kunnimalaiyaan M, Van Gompel JJ |title=Medullary thyroid cancer: the functions of raf-1 and human achaete-scute homologue-1. |journal=Thyroid |volume=15 |issue= 6 |pages= 511–21 |year= 2006 |pmid= 16029117 |doi= 10.1089/thy.2005.15.511
*cite journal | author=Ball DW, Azzoli CG, Baylin SB, "et al." |title=Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 12 |pages= 5648–52 |year= 1993 |pmid= 8390674 |doi=
*cite journal | author=Renault B, Lieman J, Ward D, "et al." |title=Localization of the human achaete-scute homolog gene (ASCL1) distal to phenylalanine hydroxylase (PAH) and proximal to tumor rejection antigen (TRA1) on chromosome 12q22-q23. |journal=Genomics |volume=30 |issue= 1 |pages= 81–3 |year= 1996 |pmid= 8595908 |doi= 10.1006/geno.1995.0012
*cite journal | author=Mao Z, Nadal-Ginard B |title=Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14371–5 |year= 1996 |pmid= 8662987 |doi=
*cite journal | author=Borges M, Linnoila RI, van de Velde HJ, "et al." |title=An achaete-scute homologue essential for neuroendocrine differentiation in the lung. |journal=Nature |volume=386 |issue= 6627 |pages= 852–5 |year= 1997 |pmid= 9126746 |doi= 10.1038/386852a0
*cite journal | author=Chen H, Biel MA, Borges MW, "et al." |title=Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. |journal=Cell Growth Differ. |volume=8 |issue= 6 |pages= 677–86 |year= 1997 |pmid= 9186001 |doi=
*cite journal | author=Lo L, Sommer L, Anderson DJ |title=MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells. |journal=Curr. Biol. |volume=7 |issue= 6 |pages= 440–50 |year= 1997 |pmid= 9197246 |doi=
*cite journal | author=Rozovskaia T, Rozenblatt-Rosen O, Sedkov Y, "et al." |title=Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins. |journal=Oncogene |volume=19 |issue= 3 |pages= 351–7 |year= 2000 |pmid= 10656681 |doi= 10.1038/sj.onc.1203307
*cite journal | author=Persson P, Jögi A, Grynfeld A, "et al." |title=HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. |journal=Biochem. Biophys. Res. Commun. |volume=274 |issue= 1 |pages= 22–31 |year= 2000 |pmid= 10903890 |doi= 10.1006/bbrc.2000.3090
*cite journal | author=Maxon ME, Herskowitz I |title=Ash1p is a site-specific DNA-binding protein that actively represses transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 4 |pages= 1495–500 |year= 2001 |pmid= 11171979 |doi= 10.1073/pnas.98.4.1495
*cite journal | author=Long RM, Gu W, Meng X, "et al." |title=An exclusively nuclear RNA-binding protein affects asymmetric localization of ASH1 mRNA and Ash1p in yeast. |journal=J. Cell Biol. |volume=153 |issue= 2 |pages= 307–18 |year= 2001 |pmid= 11309412 |doi=
*cite journal | author=Parras CM, Schuurmans C, Scardigli R, "et al." |title=Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. |journal=Genes Dev. |volume=16 |issue= 3 |pages= 324–38 |year= 2002 |pmid= 11825874 |doi= 10.1101/gad.940902
*cite journal | author=Sriuranpong V, Borges MW, Strock CL, "et al." |title=Notch signaling induces rapid degradation of achaete-scute homolog 1. |journal=Mol. Cell. Biol. |volume=22 |issue= 9 |pages= 3129–39 |year= 2002 |pmid= 11940670 |doi=
*cite journal | author=Westerman BA, Neijenhuis S, Poutsma A, "et al." |title=Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features. |journal=Clin. Cancer Res. |volume=8 |issue= 4 |pages= 1082–6 |year= 2002 |pmid= 11948117 |doi=
*cite journal | author=Letinic K, Zoncu R, Rakic P |title=Origin of GABAergic neurons in the human neocortex. |journal=Nature |volume=417 |issue= 6889 |pages= 645–9 |year= 2002 |pmid= 12050665 |doi= 10.1038/nature00779
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=de Pontual L, Népote V, Attié-Bitach T, "et al." |title=Noradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation syndrome (Ondine's curse). |journal=Hum. Mol. Genet. |volume=12 |issue= 23 |pages= 3173–80 |year= 2004 |pmid= 14532329 |doi= 10.1093/hmg/ddg339
*cite journal | author=Sippel RS, Carpenter JE, Kunnimalaiyaan M, Chen H |title=The role of human achaete-scute homolog-1 in medullary thyroid cancer cells. |journal=Surgery |volume=134 |issue= 6 |pages= 866–71; discussion 871–3 |year= 2004 |pmid= 14668716 |doi= 10.1016/S0039
*cite journal | author=Ferretti E, Di Stefano D, Zazzeroni F, "et al." |title=Human pituitary tumours express the bHLH transcription factors NeuroD1 and ASH1. |journal=J. Endocrinol. Invest. |volume=26 |issue= 10 |pages= 957–65 |year= 2004 |pmid= 14759067 |doi=
*cite journal | author=Mhawech P, Berczy M, Assaly M, "et al." |title=Human achaete-scute homologue (hASH1) mRNA level as a diagnostic marker to distinguish esthesioneuroblastoma from poorly differentiated tumors arising in the sinonasal tract. |journal=Am. J. Clin. Pathol. |volume=122 |issue= 1 |pages= 100–5 |year= 2004 |pmid= 15272537 |doi= 10.1309/QD0K-9Q1J-BH6B-5GQQExternal links
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