HOXC5

Homeobox C5, also known as HOXC5, is a human gene.cite web | title = Entrez Gene: HOXC5 homeobox C5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3222| accessdate = ]

PBB_Summary
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summary_text = This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only.cite web | title = Entrez Gene: HOXC5 homeobox C5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3222| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Arcioni L, Simeone A, Guazzi S, "et al." |title=The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins. |journal=EMBO J. |volume=11 |issue= 1 |pages= 265–77 |year= 1992 |pmid= 1346761 |doi=
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH |title=Cognate homeo-box loci mapped on homologous human and mouse chromosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 9104–8 |year= 1987 |pmid= 2878432 |doi=
*cite journal | author=Simeone A, Pannese M, Acampora D, "et al." |title=At least three human homeoboxes on chromosome 12 belong to the same transcription unit. |journal=Nucleic Acids Res. |volume=16 |issue= 12 |pages= 5379–90 |year= 1988 |pmid= 2898768 |doi=
*cite journal | author=Guazzi S, Lonigro R, Pintonello L, "et al." |title=The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. |journal=EMBO J. |volume=13 |issue= 14 |pages= 3339–47 |year= 1994 |pmid= 7913891 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Kosaki K, Kosaki R, Suzuki T, "et al." |title=Complete mutation analysis panel of the 39 human HOX genes. |journal=Teratology |volume=65 |issue= 2 |pages= 50–62 |year= 2002 |pmid= 11857506 |doi= 10.1002/tera.10009
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

External links

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