ARID1A

AT rich interactive domain 1A (SWI-like), also known as ARID1A, is a human gene.cite web | title = Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8289| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8289| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Martens JA, Winston F |title=Recent advances in understanding chromatin remodeling by Swi/Snf complexes. |journal=Curr. Opin. Genet. Dev. |volume=13 |issue= 2 |pages= 136–42 |year= 2003 |pmid= 12672490 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Wang W, Xue Y, Zhou S, "et al." |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117–30 |year= 1996 |pmid= 8804307 |doi=
*cite journal | author=Wang W, Côté J, Xue Y, "et al." |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370–82 |year= 1996 |pmid= 8895581 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Takeuchi T, Chen BK, Qiu Y, "et al." |title=Molecular cloning and expression of a novel human cDNA containing CAG repeats. |journal=Gene |volume=204 |issue= 1-2 |pages= 71–7 |year= 1998 |pmid= 9434167 |doi=
*cite journal | author=Dallas PB, Cheney IW, Liao DW, "et al." |title=p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3596–603 |year= 1998 |pmid= 9584200 |doi=
*cite journal | author=Takeuchi T, Furihata M, Heng HH, "et al." |title=Chromosomal mapping and expression of the human B120 gene. |journal=Gene |volume=213 |issue= 1-2 |pages= 189–93 |year= 1998 |pmid= 9630625 |doi=
*cite journal | author=Dallas PB, Pacchione S, Wilsker D, "et al." |title=The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3137–46 |year= 2000 |pmid= 10757798 |doi=
*cite journal | author=Nie Z, Xue Y, Yang D, "et al." |title=A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8879–88 |year= 2000 |pmid= 11073988 |doi=
*cite journal | author=Takeuchi T, Nicole S, Misaki A, "et al." |title=Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma. |journal=Am. J. Pathol. |volume=158 |issue= 2 |pages= 663–72 |year= 2001 |pmid= 11159203 |doi=
*cite journal | author=Kozmik Z, Machon O, Králová J, "et al." |title=Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex. |journal=Genomics |volume=73 |issue= 2 |pages= 140–8 |year= 2001 |pmid= 11318604 |doi= 10.1006/geno.2001.6477
*cite journal | author=Kato H, Tjernberg A, Zhang W, "et al." |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200
*cite journal | author=Lemon B, Inouye C, King DS, Tjian R |title=Selectivity of chromatin-remodelling cofactors for ligand-activated transcription. |journal=Nature |volume=414 |issue= 6866 |pages= 924–8 |year= 2002 |pmid= 11780067 |doi= 10.1038/414924a
*cite journal | author=Hurlstone AF, Olave IA, Barker N, "et al." |title=Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein. |journal=Biochem. J. |volume=364 |issue= Pt 1 |pages= 255–64 |year= 2002 |pmid= 11988099 |doi=
*cite journal | author=Inoue H, Furukawa T, Giannakopoulos S, "et al." |title=Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 41674–85 |year= 2003 |pmid= 12200431 |doi= 10.1074/jbc.M205961200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nie Z, Yan Z, Chen EH, "et al." |title=Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2942–52 |year= 2003 |pmid= 12665591 |doi=
*cite journal | author=Kitagawa H, Fujiki R, Yoshimura K, "et al." |title=The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome. |journal=Cell |volume=113 |issue= 7 |pages= 905–17 |year= 2003 |pmid= 12837248 |doi=

External links

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