ATF4

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a human gene.

PBB_Summary
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summary_text = This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.cite web | title = Entrez Gene: ATF4 activating transcription factor 4 (tax-responsive enhancer element B67)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=468| accessdate = ]

ee also

* Activating transcription factor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rutkowski DT, Kaufman RJ |title=All roads lead to ATF4. |journal=Dev. Cell |volume=4 |issue= 4 |pages= 442–4 |year= 2003 |pmid= 12689582 |doi=
*cite journal | author=Nishizawa M, Nagata S |title=cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 36–8 |year= 1992 |pmid= 1371974 |doi=
*cite journal | author=Karpinski BA, Morle GD, Huggenvik J, "et al." |title=Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 11 |pages= 4820–4 |year= 1992 |pmid= 1534408 |doi=
*cite journal | author=Hai T, Curran T |title=Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3720–4 |year= 1991 |pmid= 1827203 |doi=
*cite journal | author=Tsujimoto A, Nyunoya H, Morita T, "et al." |title=Isolation of cDNAs for DNA-binding proteins which specifically bind to a tax-responsive enhancer element in the long terminal repeat of human T-cell leukemia virus type I. |journal=J. Virol. |volume=65 |issue= 3 |pages= 1420–6 |year= 1991 |pmid= 1847461 |doi=
*cite journal | author=Hai TW, Liu F, Coukos WJ, Green MR |title=Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. |journal=Genes Dev. |volume=3 |issue= 12B |pages= 2083–90 |year= 1990 |pmid= 2516827 |doi=
*cite journal | author=Kokame K, Kato H, Miyata T |title=Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 29659–65 |year= 1997 |pmid= 8939898 |doi=
*cite journal | author=Reddy TR, Tang H, Li X, Wong-Staal F |title=Functional interaction of the HTLV-1 transactivator Tax with activating transcription factor-4 (ATF4). |journal=Oncogene |volume=14 |issue= 23 |pages= 2785–92 |year= 1997 |pmid= 9190894 |doi= 10.1038/sj.onc.1201119
*cite journal | author=Liang G, Hai T |title=Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 24088–95 |year= 1997 |pmid= 9295363 |doi=
*cite journal | author=Kawai T, Matsumoto M, Takeda K, "et al." |title=ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1642–51 |year= 1998 |pmid= 9488481 |doi=
*cite journal | author=Outinen PA, Sood SK, Pfeifer SI, "et al." |title=Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells. |journal=Blood |volume=94 |issue= 3 |pages= 959–67 |year= 1999 |pmid= 10419887 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Podust LM, Krezel AM, Kim Y |title=Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 505–13 |year= 2001 |pmid= 11018027 |doi= 10.1074/jbc.M005594200
*cite journal | author=Murphy P, Kolstø A |title=Expression of the bZIP transcription factor TCF11 and its potential dimerization partners during development. |journal=Mech. Dev. |volume=97 |issue= 1-2 |pages= 141–8 |year= 2001 |pmid= 11025215 |doi=
*cite journal | author=White JH, McIllhinney RA, Wise A, "et al." |title=The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13967–72 |year= 2001 |pmid= 11087824 |doi= 10.1073/pnas.240452197
*cite journal | author=He CH, Gong P, Hu B, "et al." |title=Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 20858–65 |year= 2001 |pmid= 11274184 |doi= 10.1074/jbc.M101198200
*cite journal | author=Siu F, Bain PJ, LeBlanc-Chaffin R, "et al." |title=ATF4 is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24120–7 |year= 2002 |pmid= 11960987 |doi= 10.1074/jbc.M201959200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bowers AJ, Scully S, Boylan JF |title=SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia. |journal=Oncogene |volume=22 |issue= 18 |pages= 2823–35 |year= 2003 |pmid= 12743605 |doi= 10.1038/sj.onc.1206367

External links

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