FOXC2

FOXC2

protein
Name = forkhead box C2 (MFH-1, mesenchyme forkhead 1)
caption =


width =
HGNCid = 3801
Symbol = FOXC2
AltSymbols = FKHL14
EntrezGene = 2303
OMIM = 602402
RefSeq = NM_005251
UniProt = Q99958
PDB =
ECnumber =
Chromosome = 16
Arm = q
Band = 22
LocusSupplementaryData = -16q24

FOXC2 is a gene associated with lymphedema distichiasis, and that has been studied to determine if it is associated with varicose veins.

FOXC2 is also involved in cancer metastases. Particularly, expression of FOXC2 is induced when epithelial cells undergo an epithelial-mesenchymal transition (EMT) and become mesenchymal looking cells. EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1. Suppression of FOXC2 expression using shRNA in a highly metastatic breast cancer model blocks their metastatic ability.

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