ING4

Inhibitor of growth family, member 4, also known as ING4, is a human gene.cite web | title = Entrez Gene: ING4 inhibitor of growth family, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51147| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.cite web | title = Entrez Gene: ING4 inhibitor of growth family, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51147| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ozer A, Bruick RK |title=Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4. |journal=Cell Cycle |volume=4 |issue= 9 |pages= 1153–6 |year= 2006 |pmid= 16096374 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hu RM, Han ZG, Song HD, "et al." |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shiseki M, Nagashima M, Pedeux RM, "et al." |title=p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity. |journal=Cancer Res. |volume=63 |issue= 10 |pages= 2373–8 |year= 2003 |pmid= 12750254 |doi=
*cite journal | author=Garkavtsev I, Kozin SV, Chernova O, "et al." |title=The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis. |journal=Nature |volume=428 |issue= 6980 |pages= 328–32 |year= 2004 |pmid= 15029197 |doi= 10.1038/nature02329
*cite journal | author=Zhang X, Xu LS, Wang ZQ, "et al." |title=ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells. |journal=FEBS Lett. |volume=570 |issue= 1-3 |pages= 7–12 |year= 2004 |pmid= 15251430 |doi= 10.1016/j.febslet.2004.06.010
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kim S, Chin K, Gray JW, Bishop JM |title=A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 46 |pages= 16251–6 |year= 2004 |pmid= 15528276 |doi= 10.1073/pnas.0407158101
*cite journal | author=Zhang X, Wang KS, Wang ZQ, "et al." |title=Nuclear localization signal of ING4 plays a key role in its binding to p53. |journal=Biochem. Biophys. Res. Commun. |volume=331 |issue= 4 |pages= 1032–8 |year= 2005 |pmid= 15882981 |doi= 10.1016/j.bbrc.2005.04.023
*cite journal | author=Ozer A, Wu LC, Bruick RK |title=The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 21 |pages= 7481–6 |year= 2005 |pmid= 15897452 |doi= 10.1073/pnas.0502716102
*cite journal | author=Gunduz M, Nagatsuka H, Demircan K, "et al." |title=Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas. |journal=Gene |volume=356 |issue= |pages= 109–17 |year= 2005 |pmid= 15935570 |doi= 10.1016/j.gene.2005.02.014
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kim SC, Sprung R, Chen Y, "et al." |title=Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. |journal=Mol. Cell |volume=23 |issue= 4 |pages= 607–18 |year= 2006 |pmid= 16916647 |doi= 10.1016/j.molcel.2006.06.026
*cite journal | author=Unoki M, Shen JC, Zheng ZM, Harris CC |title=Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. |journal=J. Biol. Chem. |volume=281 |issue= 45 |pages= 34677–86 |year= 2006 |pmid= 16973615 |doi= 10.1074/jbc.M606296200
*cite journal | author=Raho G, Miranda C, Tamborini E, "et al." |title=Detection of novel mRNA splice variants of human ING4 tumor suppressor gene. |journal=Oncogene |volume=26 |issue= 36 |pages= 5247–57 |year= 2007 |pmid= 17325660 |doi= 10.1038/sj.onc.1210335
*cite journal | author=Zhang X, Lin DH, Jin Y, "et al." |title=Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 22 |pages= 9517–22 |year= 2007 |pmid= 17517644 |doi= 10.1073/pnas.0703383104

External links

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