- HOXB4
Homeobox B4, also known as HOXB4, is a human
gene .cite web | title = Entrez Gene: HOXB4 homeobox B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3214| accessdate = ]PBB_Summary
section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.cite web | title = Entrez Gene: HOXB4 homeobox B4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3214| accessdate = ]ee also
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Homeobox References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Petrini M, Quaranta MT, Testa U, "et al." |title=Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes. |journal=Blood |volume=80 |issue= 1 |pages= 185–93 |year= 1992 |pmid= 1351762 |doi=
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Peverali FA, D'Esposito M, Acampora D, "et al." |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61–9 |year= 1991 |pmid= 1981366 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Kuliev A, Kukharenko V, Morozov G, "et al." |title=Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies. |journal=J. Assist. Reprod. Genet. |volume=13 |issue= 2 |pages= 177–81 |year= 1996 |pmid= 8688592 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Bodey B, Bodey B, Siegel SE, Kaiser HE |title=Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment. |journal=In Vivo |volume=14 |issue= 3 |pages= 419–24 |year= 2000 |pmid= 10904875 |doi=
*cite journal | author=Giannola DM, Shlomchik WD, Jegathesan M, "et al." |title=Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. |journal=J. Exp. Med. |volume=192 |issue= 10 |pages= 1479–90 |year= 2000 |pmid= 11085749 |doi=
*cite journal | author=Pan Q, Simpson RU |title=Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. |journal=J. Endocrinol. |volume=169 |issue= 1 |pages= 153–9 |year= 2001 |pmid= 11250656 |doi=
*cite journal | author=Shen WF, Krishnan K, Lawrence HJ, Largman C |title=The HOX homeodomain proteins block CBP histone acetyltransferase activity. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7509–22 |year= 2001 |pmid= 11585930 |doi= 10.1128/MCB.21.21.7509-7522.2001
*cite journal | author=Kömüves LG, Michael E, Arbeit JM, "et al." |title=HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation. |journal=Dev. Dyn. |volume=224 |issue= 1 |pages= 58–68 |year= 2002 |pmid= 11984874 |doi= 10.1002/dvdy.10085
*cite journal | author=Buske C, Feuring-Buske M, Abramovich C, "et al." |title=Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. |journal=Blood |volume=100 |issue= 3 |pages= 862–8 |year= 2002 |pmid= 12130496 |doi= 10.1182/blood-2002-01-0220
*cite journal | author=Schiedlmeier B, Klump H, Will E, "et al." |title=High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. |journal=Blood |volume=101 |issue= 5 |pages= 1759–68 |year= 2003 |pmid= 12406897 |doi= 10.1182/blood-2002-03-0767
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Theokli C, Morsi El-Kadi AS, Morgan R |title=TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation. |journal=Dev. Dyn. |volume=227 |issue= 1 |pages= 48–55 |year= 2004 |pmid= 12701098 |doi= 10.1002/dvdy.10287
*cite journal | author=Kömüves LG, Ma XK, Stelnicki E, "et al." |title=HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. |journal=Dev. Dyn. |volume=227 |issue= 2 |pages= 192–202 |year= 2004 |pmid= 12761847 |doi= 10.1002/dvdy.10290
*cite journal | author=Zhu J, Giannola DM, Zhang Y, "et al." |title=NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4. |journal=Blood |volume=102 |issue= 7 |pages= 2420–7 |year= 2003 |pmid= 12791656 |doi= 10.1182/blood-2003-01-0251External links
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