BCL11B

B-cell CLL/lymphoma 11B (zinc finger protein), also known as BCL11B, is a human gene.cite web | title = Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.cite web | title = Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64919| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Avram D, Fields A, Pretty On Top K, "et al." |title=Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10315–22 |year= 2000 |pmid= 10744719 |doi=
*cite journal | author=Satterwhite E, Sonoki T, Willis TG, "et al." |title=The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. |journal=Blood |volume=98 |issue= 12 |pages= 3413–20 |year= 2001 |pmid= 11719382 |doi=
*cite journal | author=Avram D, Fields A, Senawong T, "et al." |title=COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein. |journal=Biochem. J. |volume=368 |issue= Pt 2 |pages= 555–63 |year= 2003 |pmid= 12196208 |doi= 10.1042/BJ20020496
*cite journal | author=Wakabayashi Y, Inoue J, Takahashi Y, "et al." |title=Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 598–603 |year= 2003 |pmid= 12565905 |doi=
*cite journal | author=Rohr O, Lecestre D, Chasserot-Golaz S, "et al." |title=Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. |journal=J. Virol. |volume=77 |issue= 9 |pages= 5415–27 |year= 2003 |pmid= 12692243 |doi=
*cite journal | author=Senawong T, Peterson VJ, Avram D, "et al." |title=Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43041–50 |year= 2003 |pmid= 12930829 |doi= 10.1074/jbc.M307477200
*cite journal | author=Bezrookove V, van Zelderen-Bhola SL, Brink A, "et al." |title=A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene. |journal=Cancer Genet. Cytogenet. |volume=149 |issue= 1 |pages= 72–6 |year= 2004 |pmid= 15104287 |doi=
*cite journal | author=MacLeod RA, Nagel S, Drexler HG |title=BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia. |journal=Cancer Genet. Cytogenet. |volume=153 |issue= 1 |pages= 88–9 |year= 2004 |pmid= 15325104 |doi= 10.1016/j.cancergencyto.2004.02.020
*cite journal | author=Przybylski GK, Dik WA, Wanzeck J, "et al." |title=Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. |journal=Leukemia |volume=19 |issue= 2 |pages= 201–8 |year= 2005 |pmid= 15668700 |doi= 10.1038/sj.leu.2403619
*cite journal | author=Cismasiu VB, Adamo K, Gecewicz J, "et al." |title=BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter. |journal=Oncogene |volume=24 |issue= 45 |pages= 6753–64 |year= 2005 |pmid= 16091750 |doi= 10.1038/sj.onc.1208904
*cite journal | author=Topark-Ngarm A, Golonzhka O, Peterson VJ, "et al." |title=CTIP2 associates with the NuRD complex on the promoter of p57KIP2, a newly identified CTIP2 target gene. |journal=J. Biol. Chem. |volume=281 |issue= 43 |pages= 32272–83 |year= 2006 |pmid= 16950772 |doi= 10.1074/jbc.M602776200
*cite journal | author=Marban C, Suzanne S, Dequiedt F, "et al." |title=Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing. |journal=EMBO J. |volume=26 |issue= 2 |pages= 412–23 |year= 2007 |pmid= 17245431 |doi= 10.1038/sj.emboj.7601516
*cite journal | author=Nagel S, Scherr M, Kel A, "et al." |title=Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. |journal=Cancer Res. |volume=67 |issue= 4 |pages= 1461–71 |year= 2007 |pmid= 17308084 |doi= 10.1158/0008-5472.CAN-06-2615
*cite journal | author=Kamimura K, Mishima Y, Obata M, "et al." |title=Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages. |journal=Oncogene |volume=26 |issue= 40 |pages= 5840–50 |year= 2007 |pmid= 17369851 |doi= 10.1038/sj.onc.1210388

External links

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