TLX3

T-cell leukemia homeobox 3, also known as TLX3, is a human gene.cite web | title = Entrez Gene: TLX3 T-cell leukemia homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30012| accessdate = ]

PBB_Summary
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summary_text = RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993). [supplied by OMIM] cite web | title = Entrez Gene: TLX3 T-cell leukemia homeobox 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30012| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dear TN, Sanchez-Garcia I, Rabbitts TH |title=The HOX11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 10 |pages= 4431–5 |year= 1993 |pmid= 8099440 |doi=
*cite journal | author=Cinti R, Fava M, Sancandi M, "et al." |title=Assignment of the HOX11L2 gene to human chromosome band 5q35.1 and of its murine homolog to mouse chromosome bands 11A4-A5 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 354–5 |year= 2001 |pmid= 11435716 |doi=
*cite journal | author=Lee-Kirsch MA, Engel K, Paditz E, "et al." |title=Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 3-4 |pages= 358 |year= 2001 |pmid= 11435718 |doi=
*cite journal | author=Bernard OA, Busson-LeConiat M, Ballerini P, "et al." |title=A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia. |journal=Leukemia |volume=15 |issue= 10 |pages= 1495–504 |year= 2002 |pmid= 11587205 |doi=
*cite journal | author=Ballerini P, Blaise A, Busson-Le Coniat M, "et al." |title=HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. |journal=Blood |volume=100 |issue= 3 |pages= 991–7 |year= 2002 |pmid= 12130513 |doi= 10.1182/blood-2001-11-0093
*cite journal | author=Matera I, Bachetti T, Cinti R, "et al." |title=Mutational analysis of the RNX gene in congenital central hypoventilation syndrome. |journal=Am. J. Med. Genet. |volume=113 |issue= 2 |pages= 178–82 |year= 2003 |pmid= 12407709 |doi= 10.1002/ajmg.10746
*cite journal | author=Mauvieux L, Leymarie V, Helias C, "et al." |title=High incidence of Hox11L2 expression in children with T-ALL. |journal=Leukemia |volume=16 |issue= 12 |pages= 2417–22 |year= 2003 |pmid= 12454747 |doi= 10.1038/sj.leu.2402709
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Berger R, Dastugue N, Busson M, "et al." |title=t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Français de Cytogénétique Hématologique (GFCH). |journal=Leukemia |volume=17 |issue= 9 |pages= 1851–7 |year= 2003 |pmid= 12970786 |doi= 10.1038/sj.leu.2403061
*cite journal | author=Cavé H, Suciu S, Preudhomme C, "et al." |title=Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. |journal=Blood |volume=103 |issue= 2 |pages= 442–50 |year= 2004 |pmid= 14504110 |doi= 10.1182/blood-2003-05-1495
*cite journal | author=Su XY, Busson M, Della Valle V, "et al." |title=Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. |journal=Genes Chromosomes Cancer |volume=41 |issue= 3 |pages= 243–9 |year= 2004 |pmid= 15334547 |doi= 10.1002/gcc.20088
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ballerini P, Busson M, Fasola S, "et al." |title=NUP214-ABL1 amplification in t(5;14)/HOX11L2-positive ALL present with several forms and may have a prognostic significance. |journal=Leukemia |volume=19 |issue= 3 |pages= 468–70 |year= 2005 |pmid= 15674415 |doi= 10.1038/sj.leu.2403654
*cite journal | author=Gottardo NG, Jacoby PA, Sather HN, "et al." |title=Significance of HOX11L2/TLX3 expression in children with T-cell acute lymphoblastic leukemia treated on Children's Cancer Group protocols. |journal=Leukemia |volume=19 |issue= 9 |pages= 1705–8 |year= 2005 |pmid= 15990867 |doi= 10.1038/sj.leu.2403834
*cite journal | author=Borghini S, Vargiolu M, Di Duca M, "et al." |title=Nuclear factor Y drives basal transcription of the human TLX3, a gene overexpressed in T-cell acute lymphocytic leukemia. |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 635–43 |year= 2006 |pmid= 16966433 |doi= 10.1158/1541-7786.MCR-05-0250
*cite journal | author=Nagel S, Scherr M, Kel A, "et al." |title=Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1. |journal=Cancer Res. |volume=67 |issue= 4 |pages= 1461–71 |year= 2007 |pmid= 17308084 |doi= 10.1158/0008-5472.CAN-06-2615

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