MAX (gene)

MYC associated factor X, also known as MAX, is a human gene.cite web | title = Entrez Gene: MAX MYC associated factor X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4149| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature for some of them is unknown.cite web | title = Entrez Gene: MAX MYC associated factor X| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4149| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Grandori C, Cowley SM, James LP, Eisenman RN |title=The Myc/Max/Mad network and the transcriptional control of cell behavior. |journal=Annu. Rev. Cell Dev. Biol. |volume=16 |issue= |pages= 653–99 |year= 2001 |pmid= 11031250 |doi= 10.1146/annurev.cellbio.16.1.653
*cite journal | author=Lüscher B |title=Function and regulation of the transcription factors of the Myc/Max/Mad network. |journal=Gene |volume=277 |issue= 1-2 |pages= 1–14 |year= 2001 |pmid= 11602341 |doi=
*cite journal | author=Wechsler DS, Dang CV |title=Opposite orientations of DNA bending by c-Myc and Max. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 16 |pages= 7635–9 |year= 1992 |pmid= 1323849 |doi=
*cite journal | author=Wagner AJ, Le Beau MM, Diaz MO, Hay N |title=Expression, regulation, and chromosomal localization of the Max gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 3111–5 |year= 1992 |pmid= 1557420 |doi=
*cite journal | author=Mäkelä TP, Koskinen PJ, Västrik I, Alitalo K |title=Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation. |journal=Science |volume=256 |issue= 5055 |pages= 373–7 |year= 1992 |pmid= 1566084 |doi=
*cite journal | author=Gilladoga AD, Edelhoff S, Blackwood EM, "et al." |title=Mapping of MAX to human chromosome 14 and mouse chromosome 12 by in situ hybridization. |journal=Oncogene |volume=7 |issue= 6 |pages= 1249–51 |year= 1992 |pmid= 1594250 |doi=
*cite journal | author=Blackwood EM, Eisenman RN |title=Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. |journal=Science |volume=251 |issue= 4998 |pages= 1211–7 |year= 1991 |pmid= 2006410 |doi=
*cite journal | author=Zervos AS, Faccio L, Gatto JP, "et al." |title=Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 23 |pages= 10531–4 |year= 1995 |pmid= 7479834 |doi=
*cite journal | author=Bousset K, Henriksson M, Lüscher-Firzlaff JM, "et al." |title=Identification of casein kinase II phosphorylation sites in Max: effects on DNA-binding kinetics of Max homo- and Myc/Max heterodimers. |journal=Oncogene |volume=8 |issue= 12 |pages= 3211–20 |year= 1993 |pmid= 8247525 |doi=
*cite journal | author=Ayer DE, Kretzner L, Eisenman RN |title=Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. |journal=Cell |volume=72 |issue= 2 |pages= 211–22 |year= 1993 |pmid= 8425218 |doi=
*cite journal | author=Västrik I, Koskinen PJ, Alitalo R, Mäkelä TP |title=Alternative mRNA forms and open reading frames of the max gene. |journal=Oncogene |volume=8 |issue= 2 |pages= 503–7 |year= 1993 |pmid= 8426752 |doi=
*cite journal | author=Ferré-D'Amaré AR, Prendergast GC, Ziff EB, Burley SK |title=Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain. |journal=Nature |volume=363 |issue= 6424 |pages= 38–45 |year= 1993 |pmid= 8479534 |doi= 10.1038/363038a0
*cite journal | author=Hurlin PJ, Quéva C, Koskinen PJ, "et al." |title=Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. |journal=EMBO J. |volume=14 |issue= 22 |pages= 5646–59 |year= 1996 |pmid= 8521822 |doi=
*cite journal | author=Grandori C, Mac J, Siëbelt F, "et al." |title=Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. |journal=EMBO J. |volume=15 |issue= 16 |pages= 4344–57 |year= 1996 |pmid= 8861962 |doi=
*cite journal | author=Brownlie P, Ceska T, Lamers M, "et al." |title=The crystal structure of an intact human Max-DNA complex: new insights into mechanisms of transcriptional control. |journal=Structure |volume=5 |issue= 4 |pages= 509–20 |year= 1997 |pmid= 9115440 |doi=
*cite journal | author=Meroni G, Reymond A, Alcalay M, "et al." |title=Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. |journal=EMBO J. |volume=16 |issue= 10 |pages= 2892–906 |year= 1997 |pmid= 9184233 |doi= 10.1093/emboj/16.10.2892
*cite journal | author=Gupta MP, Amin CS, Gupta M, "et al." |title=Transcription enhancer factor 1 interacts with a basic helix-loop-helix zipper protein, Max, for positive regulation of cardiac alpha-myosin heavy-chain gene expression. |journal=Mol. Cell. Biol. |volume=17 |issue= 7 |pages= 3924–36 |year= 1997 |pmid= 9199327 |doi=
*cite journal | author=Gupta K, Anand G, Yin X, "et al." |title=Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc. |journal=Oncogene |volume=16 |issue= 9 |pages= 1149–59 |year= 1998 |pmid= 9528857 |doi= 10.1038/sj.onc.1201634
*cite journal | author=Lavigne P, Crump MP, Gagné SM, "et al." |title=Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper. |journal=J. Mol. Biol. |volume=281 |issue= 1 |pages= 165–81 |year= 1998 |pmid= 9680483 |doi= 10.1006/jmbi.1998.1914
*cite journal | author=FitzGerald MJ, Arsura M, Bellas RE, "et al." |title=Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. |journal=Oncogene |volume=18 |issue= 15 |pages= 2489–98 |year= 1999 |pmid= 10229200 |doi= 10.1038/sj.onc.1202611

External links

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