HOXB6

Homeobox B6, also known as HOXB6, is a human gene.cite web | title = Entrez Gene: HOXB6 homeobox B6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3216| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.cite web | title = Entrez Gene: HOXB6 homeobox B6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3216| accessdate = ]

ee also

* Homeobox

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scott MP |title=Vertebrate homeobox gene nomenclature. |journal=Cell |volume=71 |issue= 4 |pages= 551–3 |year= 1992 |pmid= 1358459 |doi=
*cite journal | author=Kaur S, Singh G, Stock JL, "et al." |title=Dominant mutation of the murine Hox-2.2 gene results in developmental abnormalities. |journal=J. Exp. Zool. |volume=264 |issue= 3 |pages= 323–36 |year= 1992 |pmid= 1358998 |doi= 10.1002/jez.1402640311
*cite journal | author=Shen WF, Detmer K, Simonitch-Eason TA, "et al." |title=Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. |journal=Nucleic Acids Res. |volume=19 |issue= 3 |pages= 539–45 |year= 1991 |pmid= 1672751 |doi=
*cite journal | author=McAlpine PJ, Shows TB |title=Nomenclature for human homeobox genes. |journal=Genomics |volume=7 |issue= 3 |pages= 460 |year= 1990 |pmid= 1973146 |doi=
*cite journal | author=Peverali FA, D'Esposito M, Acampora D, "et al." |title=Expression of HOX homeogenes in human neuroblastoma cell culture lines. |journal=Differentiation |volume=45 |issue= 1 |pages= 61–9 |year= 1991 |pmid= 1981366 |doi=
*cite journal | author=Giampaolo A, Acampora D, Zappavigna V, "et al." |title=Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system. |journal=Differentiation |volume=40 |issue= 3 |pages= 191–7 |year= 1989 |pmid= 2570724 |doi=
*cite journal | author=Shen WF, Largman C, Lowney P, "et al." |title=Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8536–40 |year= 1989 |pmid= 2573064 |doi=
*cite journal | author=Acampora D, D'Esposito M, Faiella A, "et al." |title=The human HOX gene family. |journal=Nucleic Acids Res. |volume=17 |issue= 24 |pages= 10385–402 |year= 1990 |pmid= 2574852 |doi=
*cite journal | author=Boncinelli E, Acampora D, Pannese M, "et al." |title=Organization of human class I homeobox genes. |journal=Genome |volume=31 |issue= 2 |pages= 745–56 |year= 1990 |pmid= 2576652 |doi=
*cite journal | author=Murphy PD, Ferguson-Smith AC, Miki T, "et al." |title=A moderately frequent RFLP identified by both SacI and BanII with a probe from the HOX2 locus in man (17q11-17q22). |journal=Nucleic Acids Res. |volume=15 |issue= 15 |pages= 6311 |year= 1987 |pmid= 2888083 |doi=
*cite journal | author=Levine M, Rubin GM, Tjian R |title=Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. |journal=Cell |volume=38 |issue= 3 |pages= 667–73 |year= 1984 |pmid= 6091895 |doi=
*cite journal | author=Chang CP, Shen WF, Rozenfeld S, "et al." |title=Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. |journal=Genes Dev. |volume=9 |issue= 6 |pages= 663–74 |year= 1995 |pmid= 7729685 |doi=
*cite journal | author=Castronovo V, Kusaka M, Chariot A, "et al." |title=Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. |journal=Biochem. Pharmacol. |volume=47 |issue= 1 |pages= 137–43 |year= 1994 |pmid= 7906121 |doi=
*cite journal | author=Apiou F, Flagiello D, Cillo C, "et al." |title=Fine mapping of human HOX gene clusters. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 114–5 |year= 1996 |pmid= 8646877 |doi=
*cite journal | author=Sawcer S, Jones HB, Feakes R, "et al." |title=A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. |journal=Nat. Genet. |volume=13 |issue= 4 |pages= 464–8 |year= 1996 |pmid= 8696343 |doi= 10.1038/ng0896-464
*cite journal | author=Zimmermann F, Rich IN |title=Mammalian homeobox B6 expression can be correlated with erythropoietin production sites and erythropoiesis during development, but not with hematopoietic or nonhematopoietic stem cell populations. |journal=Blood |volume=89 |issue= 8 |pages= 2723–35 |year= 1997 |pmid= 9108390 |doi=
*cite journal | author=Vider BZ, Zimber A, Hirsch D, "et al." |title=Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 3 |pages= 742–8 |year= 1997 |pmid= 9126347 |doi= 10.1006/bbrc.1997.6364
*cite journal | author=Ohnishi K, Tobita T, Sinjo K, "et al." |title=Modulation of homeobox B6 and B9 genes expression in human leukemia cell lines during myelomonocytic differentiation. |journal=Leuk. Lymphoma |volume=31 |issue= 5-6 |pages= 599–608 |year= 1999 |pmid= 9922051 |doi=
*cite journal | author=Fienberg AA, Nordstedt C, Belting HG, "et al." |title=Phylogenetically conserved CK-II phosphorylation site of the murine homeodomain protein Hoxb-6. |journal=J. Exp. Zool. |volume=285 |issue= 1 |pages= 76–84 |year= 1999 |pmid= 10327653 |doi=
*cite journal | author=Vider BZ, Zimber A, Chastre E, "et al." |title=Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 513–8 |year= 2000 |pmid= 10833444 |doi= 10.1006/bbrc.2000.2804

External links

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