SOX8

SRY (sex determining region Y)-box 8, also known as SOX8, is a human gene.cite web | title = Entrez Gene: SOX8 SRY (sex determining region Y)-box 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30812| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ART-16 syndrome).cite web | title = Entrez Gene: SOX8 SRY (sex determining region Y)-box 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30812| accessdate = ]

ee also

* SOX genes

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pfeifer D, Poulat F, Holinski-Feder E, "et al." |title=The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome. |journal=Genomics |volume=63 |issue= 1 |pages= 108–16 |year= 2000 |pmid= 10662550 |doi= 10.1006/geno.1999.6060
*cite journal | author=Schepers GE, Bullejos M, Hosking BM, Koopman P |title=Cloning and characterisation of the Sry-related transcription factor gene Sox8. |journal=Nucleic Acids Res. |volume=28 |issue= 6 |pages= 1473–80 |year= 2000 |pmid= 10684944 |doi=
*cite journal | author=Daniels RJ, Peden JF, Lloyd C, "et al." |title=Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. |journal=Hum. Mol. Genet. |volume=10 |issue= 4 |pages= 339–52 |year= 2001 |pmid= 11157797 |doi=
*cite journal | author=Cheng YC, Lee CJ, Badge RM, "et al." |title=Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours. |journal=Brain Res. Mol. Brain Res. |volume=92 |issue= 1-2 |pages= 193–200 |year= 2001 |pmid= 11483257 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Schepers G, Wilson M, Wilhelm D, Koopman P |title=SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 28101–8 |year= 2003 |pmid= 12732652 |doi= 10.1074/jbc.M304067200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Martin J, Han C, Gordon LA, "et al." |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187
*cite journal | author=Wissmüller S, Kosian T, Wolf M, "et al." |title=The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. |journal=Nucleic Acids Res. |volume=34 |issue= 6 |pages= 1735–44 |year= 2006 |pmid= 16582099 |doi= 10.1093/nar/gkl105

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