Neuron-derived orphan receptor 1

Nuclear receptor subfamily 4, group A, member 3
PDB rendering based on 1cit.
Available structures PDB 1cit
Identifiers
Symbols	NR4A3; CHN; CSMF; MINOR; NOR1; TEC
External IDs	OMIM: 600542 MGI: 1352457 HomoloGene: 5074 IUPHAR: NR4A3 GeneCards: NR4A3 Gene
Gene Ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • DNA binding • sequence-specific DNA binding transcription factor activity • steroid hormone receptor activity • thyroid hormone receptor activity • binding • zinc ion binding • sequence-specific DNA binding • metal ion binding Cellular component • nucleus • nucleoplasm • transcription factor complex Biological process • mesoderm formation • axon guidance • biological_process • gene expression • hippocampus development • adult behavior • organ regeneration • cellular response to stress • regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor • steroid hormone mediated signaling pathway • response to peptide hormone stimulus • negative regulation of neuron apoptosis • positive regulation of cell cycle • semicircular canal morphogenesis • neuromuscular process controlling balance • vestibular reflex • positive regulation of leukocyte apoptosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8013	18124
Ensembl	ENSG00000119508	ENSMUSG00000028341
UniProt	Q92570	Q9QZB6
RefSeq (mRNA)	NM_006981.3	NM_015743.2
RefSeq (protein)	NP_008912.2	NP_056558.1
Location (UCSC)	Chr 9: 102.58 – 102.63 Mb	Chr 4: 48.06 – 48.1 Mb
PubMed search	[1]	[2]

The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.^[1] NOR1 is a member of the nuclear receptor family of intracellular transcription factors.

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism^[2][3] and apoptosis^[4]

Interactions

Neuron-derived orphan receptor 1 has been shown to interact with SIX3.^[5][6]

See also

• NUR nuclear receptor family

References

1. ^ Hedvat CV, Irving SG (1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Mol. Endocrinol. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405. 
2. ^ Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967. 
3. ^ Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999. 
4. ^ Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (2006). "The NR4A Orphan Nuclear Receptor NOR1 Is Induced by Platelet-derived Growth Factor and Mediates Vascular Smooth Muscle Cell Proliferation". J. Biol. Chem. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1829169. 
5. ^ Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (January 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Res. 63 (2): 449–54. PMID 12543801. 
6. ^ Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Dev. Neurosci. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923. 

Further reading

• Ohkura N, Hijikuro M, Yamamoto A, Miki K (1995). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochem. Biophys. Res. Commun. 205 (3): 1959–65. doi:10.1006/bbrc.1994.2900. PMID 7811288. 
• Clark J, Benjamin H, Gill S, et al. (1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene 12 (2): 229–35. PMID 8570200. 
• Labelle Y, Zucman J, Stenman G, et al. (1996). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Hum. Mol. Genet. 4 (12): 2219–26. doi:10.1093/hmg/4.12.2219. PMID 8634690. 
• Ohkura N, Ito M, Tsukada T, et al. (1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochim. Biophys. Acta 1308 (3): 205–14. PMID 8809112. 
• Ohkura N, Ito M, Tsukada T, et al. (1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene 211 (1): 79–85. doi:10.1016/S0378-1119(98)00095-X. PMID 9573341. 
• Labelle Y, Bussières J, Courjal F, Goldring MB (1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene 18 (21): 3303–8. doi:10.1038/sj.onc.1202675. PMID 10359536. 
• Panagopoulos I, Mencinger M, Dietrich CU, et al. (2000). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene 18 (52): 7594–8. doi:10.1038/sj.onc.1203155. PMID 10602519. 
• Sjögren H, Wedell B, Meis-Kindblom JM, et al. (2001). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Res. 60 (24): 6832–5. PMID 11156374. 
• Liu D, Jia H, Holmes DI, et al. (2004). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arterioscler. Thromb. Vasc. Biol. 23 (11): 2002–7. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795. 
• Rius J, Martínez-González J, Crespo J, Badimon L (2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arterioscler. Thromb. Vasc. Biol. 24 (4): 697–702. doi:10.1161/01.ATV.0000121570.00515.dc. PMID 14962944. 
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genet. Cytogenet. 152 (2): 101–7. doi:10.1016/j.cancergencyto.2003.11.011. PMID 15262426. 
• Laflamme C, Filion C, Labelle Y (2005). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Hum. Mutat. 24 (6): 502–8. doi:10.1002/humu.20102. PMID 15523651. 
• Rius J, Martínez-González J, Crespo J, Badimon L (2006). "NOR-1 is involved in VEGF-induced endothelial cell growth". Atherosclerosis 184 (2): 276–82. doi:10.1016/j.atherosclerosis.2005.04.008. PMID 15949808. 
• Pei L, Castrillo A, Chen M, et al. (2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". J. Biol. Chem. 280 (32): 29256–62. doi:10.1074/jbc.M502606200. PMID 15964844. 
• Bonta PI, van Tiel CM, Vos M, et al. (2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arterioscler. Thromb. Vasc. Biol. 26 (10): 2288–94. doi:10.1161/01.ATV.0000238346.84458.5d. PMID 16873729. 
• Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967. 
• Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (2008). "The Orphan Nuclear Receptor, NOR-1, a Target of {beta}-Adrenergic Signaling, Regulates Gene Expression that Controls Oxidative Metabolism in Skeletal Muscle". Endocrinology 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999. 

External links

• MeSH NR4A3+protein,+human