EN2 (gene)

Engrailed homeobox 2, also known as EN2, is a human gene.cite web | title = Entrez Gene: EN2 engrailed homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2020| accessdate = ]

PBB_Summary
section_title =
summary_text = Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.cite web | title = Entrez Gene: EN2 engrailed homeobox 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2020| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Logan C, Hanks MC, Noble-Topham S, "et al." |title=Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions. |journal=Dev. Genet. |volume=13 |issue= 5 |pages= 345–58 |year= 1993 |pmid= 1363401 |doi= 10.1002/dvg.1020130505
*cite journal | author=Joyner AL, Herrup K, Auerbach BA, "et al." |title=Subtle cerebellar phenotype in mice homozygous for a targeted deletion of the En-2 homeobox. |journal=Science |volume=251 |issue= 4998 |pages= 1239–43 |year= 1991 |pmid= 1672471 |doi=
*cite journal | author=Poole SJ, Law ML, Kao FT, Lau YF |title=Isolation and chromosomal localization of the human En-2 gene. |journal=Genomics |volume=4 |issue= 3 |pages= 225–31 |year= 1989 |pmid= 2565873 |doi=
*cite journal | author=Logan C, Willard HF, Rommens JM, Joyner AL |title=Chromosomal localization of the human homeo box-containing genes, EN1 and EN2. |journal=Genomics |volume=4 |issue= 2 |pages= 206–9 |year= 1989 |pmid= 2567700 |doi=
*cite journal | author=Kozmik Z, Sure U, Rüedi D, "et al." |title=Deregulated expression of PAX5 in medulloblastoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 12 |pages= 5709–13 |year= 1995 |pmid= 7777574 |doi=
*cite journal | author=Joliot A, Trembleau A, Raposo G, "et al." |title=Association of Engrailed homeoproteins with vesicles presenting caveolae-like properties. |journal=Development |volume=124 |issue= 10 |pages= 1865–75 |year= 1997 |pmid= 9169834 |doi=
*cite journal | author= |title=A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium. |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 571–8 |year= 1998 |pmid= 9546821 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Philippe A, Martinez M, Guilloud-Bataille M, "et al." |title=Genome-wide scan for autism susceptibility genes. Paris Autism Research International Sibpair Study. |journal=Hum. Mol. Genet. |volume=8 |issue= 5 |pages= 805–12 |year= 1999 |pmid= 10196369 |doi=
*cite journal | author=Risch N, Spiker D, Lotspeich L, "et al." |title=A genomic screen of autism: evidence for a multilocus etiology. |journal=Am. J. Hum. Genet. |volume=65 |issue= 2 |pages= 493–507 |year= 1999 |pmid= 10417292 |doi=
*cite journal | author=Ashley-Koch A, Wolpert CM, Menold MM, "et al." |title=Genetic studies of autistic disorder and chromosome 7. |journal=Genomics |volume=61 |issue= 3 |pages= 227–36 |year= 2000 |pmid= 10552924 |doi= 10.1006/geno.1999.5968
*cite journal | author=Barrett S, Beck JC, Bernier R, "et al." |title=An autosomal genomic screen for autism. Collaborative linkage study of autism. |journal=Am. J. Med. Genet. |volume=88 |issue= 6 |pages= 609–15 |year= 2000 |pmid= 10581478 |doi=
*cite journal | author=Sarnat HB, Benjamin DR, Siebert JR, "et al." |title=Agenesis of the mesencephalon and metencephalon with cerebellar hypoplasia: putative mutation in the EN2 gene--report of 2 cases in early infancy. |journal=Pediatr. Dev. Pathol. |volume=5 |issue= 1 |pages= 54–68 |year= 2002 |pmid= 11815869 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhong H, Serajee FJ, Nabi R, Huq AH |title=No association between the EN2 gene and autistic disorder. |journal=J. Med. Genet. |volume=40 |issue= 1 |pages= e4 |year= 2003 |pmid= 12525552 |doi=
*cite journal | author=Foucher I, Montesinos ML, Volovitch M, "et al." |title=Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors. |journal=Development |volume=130 |issue= 9 |pages= 1867–76 |year= 2003 |pmid= 12642491 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Gharani N, Benayed R, Mancuso V, "et al." |title=Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. |journal=Mol. Psychiatry |volume=9 |issue= 5 |pages= 474–84 |year= 2004 |pmid= 15024396 |doi= 10.1038/sj.mp.4001498
*cite journal | author=Hjerrild M, Stensballe A, Rasmussen TE, "et al." |title=Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry. |journal=J. Proteome Res. |volume=3 |issue= 3 |pages= 426–33 |year= 2004 |pmid= 15253423 |doi=

External links

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