HNF1A

HNF1 homeobox A
PDB rendering based on 1ic8.
Available structures PDB 1IC8, 2GYP
Identifiers
Symbols	HNF1A; HNF-1A; HNF1; IDDM20; LFB1; MODY3; TCF-1; TCF1
External IDs	OMIM: 142410 MGI: 98504 HomoloGene: 459 GeneCards: HNF1A Gene
Gene Ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription • DNA binding • double-stranded DNA binding • sequence-specific DNA binding transcription factor activity • protein binding • transcription factor binding • protein homodimerization activity • sequence-specific DNA binding • transcription regulatory region DNA binding • protein heterodimerization activity • protein dimerization activity Cellular component • nucleus • cytoplasm • protein complex Biological process • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • insulin secretion • regulation of pronephros size • renal glucose absorption • glucose homeostasis • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • glucose import • positive regulation of transcription initiation from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6927	21405
Ensembl	ENSG00000135100	ENSMUSG00000029556
UniProt	P20823	Q66JY7
RefSeq (mRNA)	NM_000545.5	NM_009327.3
RefSeq (protein)	NP_000536.5	NP_033353.2
Location (UCSC)	Chr 12: 121.42 – 121.44 Mb	Chr 5: 115.4 – 115.42 Mb
PubMed search	[1]	[2]

HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A, is a human gene.^[1][2]

The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes.^[3]

Interactions

HNF1A has been shown to interact with PCAF,^[7] Src,^[7] RAC3,^[7] EP300,^[8] CREB-binding protein^[7] and PCBD1.^[9][10]

See also

• Hepatocyte nuclear factors
• Maturity onset diabetes of the young

References

1. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333. 
2. ^ Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nat. Genet. 9 (4): 418–23. doi:10.1038/ng0495-418. PMID 7795649. 
3. ^ Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (October 1987). "Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters". Science 238 (4827): 688–92. doi:10.1126/science.3499668. PMID 3499668. 
4. ^ Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ (May 2001). "Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors". Drug Metab. Dispos. 29 (5): 623–33. PMID 11302926. http://dmd.aspetjournals.org/cgi/content/abstract/29/5/623. 
5. ^ Rufibach LE, Duncan SA, Battle M, Deeb SS (July 2006). "Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter". J. Lipid Res. 47 (7): 1463–77. doi:10.1194/jlr.M600082-JLR200. PMID 16603721. 
6. ^ ^{a b} Bulla GA, Kraus DM (December 2004). "Dissociation of the hepatic phenotype from HNF4 and HNF1alpha expression". Biosci. Rep. 24 (6): 595–608. doi:10.1007/s10540-005-2794-8. PMID 16158197. 
7. ^ ^{a b c d} Soutoglou, E; Papafotiou G, Katrakili N, Talianidis I (Apr. 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. (UNITED STATES) 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539. 
8. ^ Ban, Nobuhiro; Yamada Yuichiro, Someya Yoshimichi, Miyawaki Kazumasa, Ihara Yu, Hosokawa Masaya, Toyokuni Shinya, Tsuda Kinsuke, Seino Yutaka (May. 2002). "Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter". Diabetes (United States) 51 (5): 1409–18. doi:10.2337/diabetes.51.5.1409. ISSN 0012-1797. PMID 11978637. 
9. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
10. ^ Sourdive, D J; Transy C, Garbay S, Yaniv M (Apr. 1997). "The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity". Nucleic Acids Res. (ENGLAND) 25 (8): 1476–84. doi:10.1093/nar/25.8.1476. ISSN 0305-1048. PMC 146627. PMID 9092652. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146627. 

Further reading

• Eastman Q, Grosschedl R (1999). "Regulation of LEF-1/TCF transcription factors by Wnt and other signals". Curr. Opin. Cell Biol. 11 (2): 233–40. doi:10.1016/S0955-0674(99)80031-3. PMID 10209158. 
• Bioulac-Sage P, Blanc JF, Rebouissou S, et al. (2007). "Genotype phenotype classification of hepatocellular adenoma". World J. Gastroenterol. 13 (19): 2649–54. PMID 17569132.