SOX12

SRY (sex determining region Y)-box 12, also known as SOX12, is a human gene.cite web | title = Entrez Gene: SOX12 SRY (sex determining region Y)-box 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6666| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types.cite web | title = Entrez Gene: SOX12 SRY (sex determining region Y)-box 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6666| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bowles J, Schepers G, Koopman P |title=Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators. |journal=Dev. Biol. |volume=227 |issue= 2 |pages= 239–55 |year= 2001 |pmid= 11071752 |doi= 10.1006/dbio.2000.9883
*cite journal | author=Weiss MA |title=Floppy SOX: mutual induced fit in hmg (high-mobility group) box-DNA recognition. |journal=Mol. Endocrinol. |volume=15 |issue= 3 |pages= 353–62 |year= 2001 |pmid= 11222737 |doi=
*cite journal | author=Adams MD, Kerlavage AR, Fleischmann RD, "et al." |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=
*cite journal | author=Gozé C, Poulat F, Berta P |title=Partial cloning of SOX-11 and SOX-12, two new human SOX genes. |journal=Nucleic Acids Res. |volume=21 |issue= 12 |pages= 2943 |year= 1993 |pmid= 8332506 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Jay P, Sahly I, Gozé C, "et al." |title=SOX22 is a new member of the SOX gene family, mainly expressed in human nervous tissue. |journal=Hum. Mol. Genet. |volume=6 |issue= 7 |pages= 1069–77 |year= 1997 |pmid= 9215677 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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