MNDA

Myeloid cell nuclear differentiation antigen, also known as MNDA, is a human gene.cite web | title = Entrez Gene: MNDA myeloid cell nuclear differentiation antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332| accessdate = ]

PBB_Summary
section_title =
summary_text = The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.cite web | title = Entrez Gene: MNDA myeloid cell nuclear differentiation antigen| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4332| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Burrus GR, Briggs JA, Briggs RC |title=Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins. |journal=J. Cell. Biochem. |volume=48 |issue= 2 |pages= 190–202 |year= 1992 |pmid= 1377701 |doi= 10.1002/jcb.240480210
*cite journal | author=Briggs JA, Burrus GR, Stickney BD, Briggs RC |title=Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. |journal=J. Cell. Biochem. |volume=49 |issue= 1 |pages= 82–92 |year= 1992 |pmid= 1644857 |doi= 10.1002/jcb.240490114
*cite journal | author=Ott J, Fràter-Schröder M |title=Absence of linkage between transcobalamin II and ABO. |journal=Hum. Genet. |volume=59 |issue= 2 |pages= 164–5 |year= 1982 |pmid= 7327575 |doi=
*cite journal | author=Briggs RC, Briggs JA, Ozer J, "et al." |title=The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. |journal=Blood |volume=83 |issue= 8 |pages= 2153–62 |year= 1994 |pmid= 7512843 |doi=
*cite journal | author=Dawson MJ, Trapani JA, Briggs RC, "et al." |title=The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. |journal=Immunogenetics |volume=41 |issue= 1 |pages= 40–3 |year= 1995 |pmid= 7806273 |doi=
*cite journal | author=Briggs R, Dworkin L, Briggs J, "et al." |title=Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. |journal=J. Cell. Biochem. |volume=54 |issue= 2 |pages= 198–206 |year= 1994 |pmid= 8175894 |doi= 10.1002/jcb.240540208
*cite journal | author=Xie J, Briggs JA, Briggs RC |title=Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. |journal=J. Cell. Biochem. |volume=70 |issue= 4 |pages= 489–506 |year= 1998 |pmid= 9712147 |doi=
*cite journal | author=Doggett KL, Briggs JA, Linton MF, "et al." |title=Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression. |journal=J. Cell. Biochem. |volume=86 |issue= 1 |pages= 56–66 |year= 2002 |pmid= 12112016 |doi= 10.1002/jcb.10190
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Fukushi M, Higuchi M, Oie M, "et al." |title=Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha. |journal=Virus Genes |volume=27 |issue= 3 |pages= 237–47 |year= 2004 |pmid= 14618084 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Briggs RC, Atkinson JB, Miranda RN |title=Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis. |journal=J. Cell. Biochem. |volume=95 |issue= 2 |pages= 293–301 |year= 2005 |pmid= 15778972 |doi= 10.1002/jcb.20435
*cite journal | author=Asefa B, Dermott JM, Kaldis P, "et al." |title=p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation. |journal=FEBS Lett. |volume=580 |issue= 5 |pages= 1205–14 |year= 2006 |pmid= 16458891 |doi= 10.1016/j.febslet.2006.01.032
*cite journal | author=Briggs RC, Shults KE, Flye LA, "et al." |title=Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. |journal=Cancer Res. |volume=66 |issue= 9 |pages= 4645–51 |year= 2006 |pmid= 16651415 |doi= 10.1158/0008-5472.CAN-06-0229

External links

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