Jumonji, AT rich interactive domain 1D, also known as JARID1D, is a human gene.cite web | title = Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8284| accessdate = ]

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.cite web | title = Entrez Gene: JARID1D jumonji, AT rich interactive domain 1D| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8284| accessdate = ]


Further reading

citations =
*cite journal | author=Simpson E, Scott D, Chandler P |title=The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. |journal=Annu. Rev. Immunol. |volume=15 |issue= |pages= 39–61 |year= 1997 |pmid= 9143681 |doi= 10.1146/annurev.immunol.15.1.39
*cite journal | author=Wolf U |title=The serologically detected H-Y antigen revisited. |journal=Cytogenet. Cell Genet. |volume=80 |issue= 1-4 |pages= 232–5 |year= 1998 |pmid= 9678364 |doi=
*cite journal | author=Agulnik AI, Mitchell MJ, Lerner JL, "et al." |title=A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. |journal=Hum. Mol. Genet. |volume=3 |issue= 6 |pages= 873–8 |year= 1994 |pmid= 7524912 |doi=
*cite journal | author=Wang W, Meadows LR, den Haan JM, "et al." |title=Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein. |journal=Science |volume=269 |issue= 5230 |pages= 1588–90 |year= 1995 |pmid= 7667640 |doi=
*cite journal | author=Kent-First MG, Maffitt M, Muallem A, "et al." |title=Gene sequence and evolutionary conservation of human SMCY. |journal=Nat. Genet. |volume=14 |issue= 2 |pages= 128–9 |year= 1996 |pmid= 8841177 |doi= 10.1038/ng1096-128
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=Agulnik AI, Bishop CE, Lerner JL, "et al." |title=Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. |journal=Mamm. Genome |volume=8 |issue= 2 |pages= 134–8 |year= 1997 |pmid= 9060413 |doi=
*cite journal | author=Rufer N, Wolpert E, Helg C, "et al." |title=HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation. |journal=Transplantation |volume=66 |issue= 7 |pages= 910–6 |year= 1998 |pmid= 9798702 |doi=
*cite journal | author=Lau YF, Zhang J |title=Expression analysis of thirty one Y chromosome genes in human prostate cancer. |journal=Mol. Carcinog. |volume=27 |issue= 4 |pages= 308–21 |year= 2000 |pmid= 10747295 |doi=
*cite journal | author=Shen P, Wang F, Underhill PA, "et al." |title=Population genetic implications from sequence variation in four Y chromosome genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 13 |pages= 7354–9 |year= 2000 |pmid= 10861003 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, "et al." |title=The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. |journal=Nature |volume=423 |issue= 6942 |pages= 825–37 |year= 2003 |pmid= 12815422 |doi= 10.1038/nature01722
*cite journal | author=Agate RJ, Choe M, Arnold AP |title=Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches. |journal=Mol. Biol. Evol. |volume=21 |issue= 2 |pages= 384–96 |year= 2004 |pmid= 14660691 |doi= 10.1093/molbev/msh027
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Miklos DB, Kim HT, Miller KH, "et al." |title=Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission. |journal=Blood |volume=105 |issue= 7 |pages= 2973–8 |year= 2005 |pmid= 15613541 |doi= 10.1182/blood-2004-09-3660
*cite journal | author=Piper KP, McLarnon A, Arrazi J, "et al." |title=Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus. |journal=Biol. Reprod. |volume=76 |issue= 1 |pages= 96–101 |year= 2007 |pmid= 16988213 |doi= 10.1095/biolreprod.106.055426
*cite journal | author=Iwase S, Lan F, Bayliss P, "et al." |title=The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. |journal=Cell |volume=128 |issue= 6 |pages= 1077–88 |year= 2007 |pmid= 17320160 |doi= 10.1016/j.cell.2007.02.017
*cite journal | author=Lee MG, Norman J, Shilatifard A, Shiekhattar R |title=Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. |journal=Cell |volume=128 |issue= 5 |pages= 877–87 |year= 2007 |pmid= 17320162 |doi= 10.1016/j.cell.2007.02.004

External links


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  • Minor histocompatibility antigen — are receptors on the cell surface of donated organs that are known to give an immunological response in some organ transplants[1]. They cause problems of rejection less frequently than those of the major histocompatibility complex (MHC). Minor… …   Wikipedia

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