HHEX

Hematopoietically expressed homeobox, also known as HHEX, is a human gene.cite web | title = Entrez Gene: HHEX hematopoietically expressed homeobox| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3087| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the homeobox family of transcription factors, many of which are involved in developmental processes. Expression in specific hematopoietic lineages suggests that this protein may play a role in hematopoietic differentiation.cite web | title = Entrez Gene: HHEX hematopoietically expressed homeobox| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3087| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Neidle S, Goodwin GH |title=A homology-based molecular model of the proline-rich homeodomain protein Prh, from haematopoietic cells. |journal=FEBS Lett. |volume=345 |issue= 2-3 |pages= 93–8 |year= 1994 |pmid= 7911091 |doi=
*cite journal | author=Crompton MR, Bartlett TJ, MacGregor AD, "et al." |title=Identification of a novel vertebrate homeobox gene expressed in haematopoietic cells. |journal=Nucleic Acids Res. |volume=20 |issue= 21 |pages= 5661–7 |year= 1993 |pmid= 1360645 |doi=
*cite journal | author=Manfioletti G, Gattei V, Buratti E, "et al." |title=Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. |journal=Blood |volume=85 |issue= 5 |pages= 1237–45 |year= 1995 |pmid= 7858254 |doi=
*cite journal | author=Bedford FK, Ashworth A, Enver T, Wiedemann LM |title=HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. |journal=Nucleic Acids Res. |volume=21 |issue= 5 |pages= 1245–9 |year= 1993 |pmid= 8096636 |doi=
*cite journal | author=Hromas R, Radich J, Collins S |title=PCR cloning of an orphan homeobox gene (PRH) preferentially expressed in myeloid and liver cells. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 976–83 |year= 1993 |pmid= 8103988 |doi= 10.1006/bbrc.1993.2140
*cite journal | author=Topcu Z, Mack DL, Hromas RA, Borden KL |title=The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. |journal=Oncogene |volume=18 |issue= 50 |pages= 7091–100 |year= 2000 |pmid= 10597310 |doi= 10.1038/sj.onc.1203201
*cite journal | author=Pellizzari L, D'Elia A, Rustighi A, "et al." |title=Expression and function of the homeodomain-containing protein Hex in thyroid cells. |journal=Nucleic Acids Res. |volume=28 |issue= 13 |pages= 2503–11 |year= 2000 |pmid= 10871399 |doi=
*cite journal | author=Schaefer LK, Wang S, Schaefer TS |title=Functional interaction of Jun and homeodomain proteins. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43074–82 |year= 2001 |pmid= 11551904 |doi= 10.1074/jbc.M102552200
*cite journal | author=Morgutti M, Demori E, Pecile V, "et al." |title=Genomic organization and chromosome mapping of the human homeobox gene HHEX. |journal=Cytogenet. Cell Genet. |volume=94 |issue= 1-2 |pages= 30–2 |year= 2001 |pmid= 11701950 |doi=
*cite journal | author=D'Elia AV, Tell G, Russo D, "et al." |title=Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1376–83 |year= 2002 |pmid= 11889211 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Topisirovic I, Culjkovic B, Cohen N, "et al." |title=The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth. |journal=EMBO J. |volume=22 |issue= 3 |pages= 689–703 |year= 2003 |pmid= 12554669 |doi= 10.1093/emboj/cdg069
*cite journal | author=Nakagawa T, Abe M, Yamazaki T, "et al." |title=HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=23 |issue= 2 |pages= 231–7 |year= 2003 |pmid= 12588764 |doi=
*cite journal | author=Puppin C, D'Elia AV, Pellizzari L, "et al." |title=Thyroid-specific transcription factors control Hex promoter activity. |journal=Nucleic Acids Res. |volume=31 |issue= 7 |pages= 1845–52 |year= 2003 |pmid= 12655000 |doi=
*cite journal | author=Bess KL, Swingler TE, Rivett AJ, "et al." |title=The transcriptional repressor protein PRH interacts with the proteasome. |journal=Biochem. J. |volume=374 |issue= Pt 3 |pages= 667–75 |year= 2003 |pmid= 12826010 |doi= 10.1042/BJ20030769
*cite journal | author=George A, Morse HC, Justice MJ |title=The homeobox gene Hex induces T-cell-derived lymphomas when overexpressed in hematopoietic precursor cells. |journal=Oncogene |volume=22 |issue= 43 |pages= 6764–73 |year= 2003 |pmid= 14555989 |doi= 10.1038/sj.onc.1206822
*cite journal | author=Minami T, Murakami T, Horiuchi K, "et al." |title=Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 20626–35 |year= 2004 |pmid= 15016828 |doi= 10.1074/jbc.M308730200
*cite journal | author=Puppin C, Presta I, D'Elia AV, "et al." |title=Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter. |journal=Mol. Cell. Endocrinol. |volume=214 |issue= 1-2 |pages= 117–25 |year= 2004 |pmid= 15062550 |doi= 10.1016/j.mce.2003.10.061
*cite journal | author=Swingler TE, Bess KL, Yao J, "et al." |title=The proline-rich homeodomain protein recruits members of the Groucho/Transducin-like enhancer of split protein family to co-repress transcription in hematopoietic cells. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34938–47 |year= 2004 |pmid= 15187083 |doi= 10.1074/jbc.M404488200

External links

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