CBFA2T3

Core-binding factor, runt domain, alpha subunit 2; translocated to, 3, also known as CBFA2T3, is a human gene.cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = ]

PBB_Summary
section_title =
summary_text = The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the Golgi apparatus.cite web | title = Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=863| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kitabayashi I, Ida K, Morohoshi F, "et al." |title=The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 846–58 |year= 1998 |pmid= 9447981 |doi=
*cite journal | author=Gamou T, Kitamura E, Hosoda F, "et al." |title=The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family. |journal=Blood |volume=91 |issue= 11 |pages= 4028–37 |year= 1998 |pmid= 9596646 |doi=
*cite journal | author=Calabi F, Cilli V |title=CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. |journal=Genomics |volume=52 |issue= 3 |pages= 332–41 |year= 1998 |pmid= 9790752 |doi= 10.1006/geno.1998.5429
*cite journal | author=Schillace RV, Andrews SF, Liberty GA, "et al." |title=Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes. |journal=J. Immunol. |volume=168 |issue= 4 |pages= 1590–9 |year= 2002 |pmid= 11823486 |doi=
*cite journal | author=Kondoh K, Nakata Y, Furuta T, "et al." |title=A pediatric case of secondary leukemia associated with t(16;21)(q24;q22) exhibiting the chimeric AML1-MTG16 gene. |journal=Leuk. Lymphoma |volume=43 |issue= 2 |pages= 415–20 |year= 2003 |pmid= 11999578 |doi=
*cite journal | author=Kochetkova M, McKenzie OL, Bais AJ, "et al." |title=CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3. |journal=Cancer Res. |volume=62 |issue= 16 |pages= 4599–604 |year= 2002 |pmid= 12183414 |doi=
*cite journal | author=Powell JA, Gardner AE, Bais AJ, "et al." |title=Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes. |journal=Genomics |volume=80 |issue= 3 |pages= 303–10 |year= 2003 |pmid= 12213200 |doi=
*cite journal | author=Hoogeveen AT, Rossetti S, Stoyanova V, "et al." |title=The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. |journal=Oncogene |volume=21 |issue= 43 |pages= 6703–12 |year= 2002 |pmid= 12242670 |doi= 10.1038/sj.onc.1205882
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lindberg SR, Olsson A, Persson AM, Olsson I |title=Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. |journal=Eur. J. Haematol. |volume=71 |issue= 6 |pages= 439–47 |year= 2004 |pmid= 14703694 |doi=
*cite journal | author=Ibañez V, Sharma A, Buonamici S, "et al." |title=AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation. |journal=Cancer Res. |volume=64 |issue= 13 |pages= 4547–54 |year= 2004 |pmid= 15231665 |doi= 10.1158/0008-5472.CAN-03-3689
*cite journal | author=Kumar R, Manning J, Spendlove HE, "et al." |title=ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. |journal=Mol. Cancer Res. |volume=4 |issue= 9 |pages= 655–65 |year= 2006 |pmid= 16966434 |doi= 10.1158/1541-7786.MCR-05-0249

External links

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