Transcription Factor II D
- Transcription Factor II D
Transcription Factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = p636-637 | isbn = 0-13-144946-X | oclc = | doi = ] TFIID is itself composed of several subunits called TBP-associated factors (TAFs, of which there are 14) and the TATA Binding Protein (TBP). ]In a test tube, only TBP is necessary for transcription at promoters that contain a TATA box.[cite journal | author = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77] TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to. ]Subunits in the TFIID complex include:
* TBP (TATA binding protein)
* TAF1 (TAFII250)
* TAF2 (CIF150)
* TAF4 (TAFII130/135)
* TAF4B (TAFII105)
* TAF5 (TAFII100)
* TAF6 (TAFII70/80)
* TAF7 (TAFII55)
* TAF9 (TAFII31/32)
* TAF10 (TAFII30)
* TAF11 (TAFII28)
* TAF12 (TAFII20/15)
* TAF13 (TAFII18)
* TAF15 (TAFII68)
See also
* Transcription (genetics)
* Eukaryotic transcription
References
External links
*
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Transcription Factor II F — protein Name = general transcription factor IIF, polypeptide 1, 74kDa caption = width = HGNCid = 4652 Symbol = GTF2F1 AltSymbols = TFIIF, BTF4, RAP74 EntrezGene = 2962 OMIM = 189968 RefSeq = NM 002096 UniProt = P35269 PDB = ECnumber = Chromosome … Wikipedia
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transcription factor — ▪ biology molecule that controls the activity of a gene by determining whether the gene s DNA (deoxyribonucleic acid) is transcribed into RNA (ribonucleic acid). The enzyme RNA polymerase catalyzes the chemical reactions that synthesize RNA … Universalium
Transcription Factor II H — protein Name= general transcription factor IIH, polypeptide 1, 62kDa caption= width= HGNCid=4655 Symbol=GTF2H1 AltSymbols= BTF2 EntrezGene=2965 OMIM=189972 RefSeq=NM 005316 UniProt=P32780 PDB= ECnumber= Chromosome=11 Arm=p Band=15.1… … Wikipedia
transcription factor — Protein required for recognition by RNA polymerases of specific stimulatory sequences in eukaryotic genes. Several are known that activate transcription by RNA polymerase II when bound to upstream promoters. Transcription of the 5S RNA gene in… … Dictionary of molecular biology
transcription factor — noun Date: 1972 any of various proteins that bind to DNA and play a role in the regulation of gene expression by promoting transcription … New Collegiate Dictionary
