MYBL2

V-myb myeloblastosis viral oncogene homolog (avian)-like 2, also known as MYBL2, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.cite web | title = Entrez Gene: MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4605| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Golay J, Cusmano G, Introna M |title=Independent regulation of c-myc, B-myb, and c-myb gene expression by inducers and inhibitors of proliferation in human B lymphocytes. |journal=J. Immunol. |volume=149 |issue= 1 |pages= 300–8 |year= 1992 |pmid= 1376749 |doi=
*cite journal | author=Reiss K, Travali S, Calabretta B, Baserga R |title=Growth regulated expression of B-myb in fibroblasts and hematopoietic cells. |journal=J. Cell. Physiol. |volume=148 |issue= 3 |pages= 338–43 |year= 1991 |pmid= 1717494 |doi= 10.1002/jcp.1041480303
*cite journal | author=Golay J, Capucci A, Arsura M, "et al." |title=Expression of c-myb and B-myb, but not A-myb, correlates with proliferation in human hematopoietic cells. |journal=Blood |volume=77 |issue= 1 |pages= 149–58 |year= 1991 |pmid= 1984793 |doi=
*cite journal | author=Nomura N, Takahashi M, Matsui M, "et al." |title=Isolation of human cDNA clones of myb-related genes, A-myb and B-myb. |journal=Nucleic Acids Res. |volume=16 |issue= 23 |pages= 11075–89 |year= 1989 |pmid= 3060855 |doi=
*cite journal | author=Lam EW, Bennett JD, Watson RJ |title=Cell-cycle regulation of human B-myb transcription. |journal=Gene |volume=160 |issue= 2 |pages= 277–81 |year= 1995 |pmid= 7642110 |doi=
*cite journal | author=Takemoto Y, Tashiro S, Handa H, Ishii S |title=Multiple nuclear localization signals of the B-myb gene product. |journal=FEBS Lett. |volume=350 |issue= 1 |pages= 55–60 |year= 1994 |pmid= 8062924 |doi=
*cite journal | author=Zhou W, Takuwa N, Kumada M, Takuwa Y |title=E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 1 |pages= 191–8 |year= 1994 |pmid= 8123011 |doi= 10.1006/bbrc.1994.1213
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Arsura M, Luchetti MM, Erba E, "et al." |title=Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines. |journal=Blood |volume=83 |issue= 7 |pages= 1778–90 |year= 1994 |pmid= 8142646 |doi=
*cite journal | author=Nakagoshi H, Takemoto Y, Ishii S |title=Functional domains of the human B-myb gene product. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14161–7 |year= 1993 |pmid= 8314782 |doi=
*cite journal | author=Noben-Trauth K, Copeland NG, Gilbert DJ, "et al." |title=Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. |journal=Genomics |volume=35 |issue= 3 |pages= 610–2 |year= 1996 |pmid= 8812502 |doi= 10.1006/geno.1996.0408
*cite journal | author=Sala A, Kundu M, Casella I, "et al." |title=Activation of human B-MYB by cyclins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 2 |pages= 532–6 |year= 1997 |pmid= 9012818 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Saville MK, Watson RJ |title=The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. |journal=Oncogene |volume=17 |issue= 21 |pages= 2679–89 |year= 1998 |pmid= 9840932 |doi= 10.1038/sj.onc.1202503
*cite journal | author=Bartsch O, Horstmann S, Toprak K, "et al." |title=Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. |journal=Eur. J. Biochem. |volume=260 |issue= 2 |pages= 384–91 |year= 1999 |pmid= 10095772 |doi=
*cite journal | author=Kim T, Jung H, Min S, "et al." |title=B-myb proto-oncogene products interact in vivo with each other via the carboxy-terminal conserved region. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 363–8 |year= 1999 |pmid= 10544265 |doi=
*cite journal | author=Johnson TK, Schweppe RE, Septer J, Lewis RE |title=Phosphorylation of B-Myb regulates its transactivation potential and DNA binding. |journal=J. Biol. Chem. |volume=274 |issue= 51 |pages= 36741–9 |year= 2000 |pmid= 10593981 |doi=
*cite journal | author=Horstmann S, Ferrari S, Klempnauer KH |title=Regulation of B-Myb activity by cyclin D1. |journal=Oncogene |volume=19 |issue= 2 |pages= 298–306 |year= 2000 |pmid= 10645009 |doi= 10.1038/sj.onc.1203302
*cite journal | author=De Falco G, Bagella L, Claudio PP, "et al." |title=Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation. |journal=Oncogene |volume=19 |issue= 3 |pages= 373–9 |year= 2000 |pmid= 10656684 |doi= 10.1038/sj.onc.1203305
*cite journal | author=Cervellera MN, Sala A |title=Poly(ADP-ribose) polymerase is a B-MYB coactivator. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10692–6 |year= 2000 |pmid= 10744766 |doi=

External links

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