RAR-related orphan receptor gamma

RAR-related orphan receptor gamma (ROR-γ) is a member of the nuclear receptor family of transcription factors. ROR-γ is encoded by the gene|RORC gene (RAR-related orphan receptor C).

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summary_text = The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: RORC RAR-related orphan receptor C| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6097| accessdate = ]

ee also

* RAR-related orphan receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Winoto A, Littman DR |title=Nuclear hormone receptors in T lymphocytes. |journal=Cell |volume=109 Suppl |issue= |pages= S57–66 |year= 2002 |pmid= 11983153 |doi=10.1016/S0092-8674(02)00710-9
*cite journal | author=Huang Z, Xie H, Wang R, Sun Z |title=Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity. |journal=Expert Opin. Ther. Targets |volume=11 |issue= 6 |pages= 737–43 |year= 2007 |pmid= 17504012 |doi= 10.1517/14728222.11.6.737
*cite journal | author=Hirose T, Smith RJ, Jetten AM |title=ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 3 |pages= 1976–83 |year= 1995 |pmid= 7811290 |doi= 10.1006/bbrc.1994.2902
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Medvedev A, Chistokhina A, Hirose T, Jetten AM |title=Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. |journal=Genomics |volume=46 |issue= 1 |pages= 93–102 |year= 1998 |pmid= 9403063 |doi= 10.1006/geno.1997.4980
*cite journal | author=Villey I, de Chasseval R, de Villartay JP |title=RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter. |journal=Eur. J. Immunol. |volume=29 |issue= 12 |pages= 4072–80 |year= 2000 |pmid= 10602018 |doi=10.1002/(SICI)1521-4141(199912)29:12<4072::AID-IMMU4072>3.0.CO;2-E
*cite journal | author=Sun Z, Unutmaz D, Zou YR, "et al." |title=Requirement for RORgamma in thymocyte survival and lymphoid organ development. |journal=Science |volume=288 |issue= 5475 |pages= 2369–73 |year= 2000 |pmid= 10875923 |doi=10.1126/science.288.5475.2369
*cite journal | author=Kurebayashi S, Ueda E, Sakaue M, "et al." |title=Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 18 |pages= 10132–7 |year= 2000 |pmid= 10963675 |doi=10.1073/pnas.97.18.10132
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 | doi_brokendate=2008-10-03
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang H, Chu W, Das SK, "et al." |title=Molecular screening and association studies of retinoid-related orphan receptor gamma (RORC): a positional and functional candidate for type 2 diabetes. |journal=Mol. Genet. Metab. |volume=79 |issue= 3 |pages= 176–82 |year= 2004 |pmid= 12855222 |doi=10.1016/S1096-7192(03)00096-9
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Weaver CT, Murphy KM |title=T-cell subsets: the more the merrier. |journal=Curr. Biol. |volume=17 |issue= 2 |pages= R61–3 |year= 2007 |pmid= 17240331 |doi= 10.1016/j.cub.2006.12.015

External links

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