HAND2

Heart and neural crest derivatives expressed 2, also known as HAND2, is a human gene.cite web | title = Entrez Gene: HAND2 heart and neural crest derivatives expressed 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9464| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.cite web | title = Entrez Gene: HAND2 heart and neural crest derivatives expressed 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9464| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Srivastava D |title=HAND proteins: molecular mediators of cardiac development and congenital heart disease. |journal=Trends Cardiovasc. Med. |volume=9 |issue= 1-2 |pages= 11–8 |year= 1999 |pmid= 10189962 |doi=
*cite journal | author=Firulli AB, McFadden DG, Lin Q, "et al." |title=Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 266–70 |year= 1998 |pmid= 9500550 |doi= 10.1038/ng0398-266
*cite journal | author=Russell MW, Kemp P, Wang L, "et al." |title=Molecular cloning of the human HAND2 gene. |journal=Biochim. Biophys. Acta |volume=1443 |issue= 3 |pages= 393–9 |year= 1999 |pmid= 9878849 |doi=
*cite journal | author=Firulli BA, Hadzic DB, McDaid JR, Firulli AB |title=The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33567–73 |year= 2000 |pmid= 10924525 |doi= 10.1074/jbc.M005888200
*cite journal | author=McFadden DG, Charité J, Richardson JA, "et al." |title=A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart. |journal=Development |volume=127 |issue= 24 |pages= 5331–41 |year= 2001 |pmid= 11076755 |doi=
*cite journal | author=Dai YS, Cserjesi P |title=The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 12604–12 |year= 2002 |pmid= 11812799 |doi= 10.1074/jbc.M200283200
*cite journal | author=Dai YS, Cserjesi P, Markham BE, Molkentin JD |title=The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24390–8 |year= 2002 |pmid= 11994297 |doi= 10.1074/jbc.M202490200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Srivastava D, Gottlieb PD, Olson EN |title=Molecular mechanisms of ventricular hypoplasia. |journal=Cold Spring Harb. Symp. Quant. Biol. |volume=67 |issue= |pages= 121–5 |year= 2003 |pmid= 12858532 |doi=
*cite journal | author=Rychlik JL, Gerbasi V, Lewis EJ |title=The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49652–60 |year= 2004 |pmid= 14506227 |doi= 10.1074/jbc.M308577200
*cite journal | author=Firulli BA, Howard MJ, McDaid JR, "et al." |title=PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1225–37 |year= 2004 |pmid= 14636580 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Murakami M, Kataoka K, Tominaga J, "et al." |title=Differential cooperation between dHAND and three different E-proteins. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 1 |pages= 168–74 |year= 2004 |pmid= 15351717 |doi= 10.1016/j.bbrc.2004.08.072
*cite journal | author=Rychlik JL, Hsieh M, Eiden LE, Lewis EJ |title=Phox2 and dHAND transcription factors select shared and unique target genes in the noradrenergic cell type. |journal=J. Mol. Neurosci. |volume=27 |issue= 3 |pages= 281–92 |year= 2006 |pmid= 16280598 |doi=
*cite journal | author=Han Z, Yi P, Li X, Olson EN |title=Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis. |journal=Development |volume=133 |issue= 6 |pages= 1175–82 |year= 2006 |pmid= 16467358 |doi= 10.1242/dev.02285

External links

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