POU4F2

POU domain, class 4, transcription factor 2, also known as POU4F2, is a human gene.cite web | title = Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458| accessdate = ]

PBB_Summary
section_title =
summary_text = POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons. [supplied by OMIM] cite web | title = Entrez Gene: POU4F2 POU domain, class 4, transcription factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5458| accessdate = ]

ee also

* BRN-3

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Xiang M, Zhou L, Macke JP, "et al." |title=The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. |journal=J. Neurosci. |volume=15 |issue= 7 Pt 1 |pages= 4762–85 |year= 1995 |pmid= 7623109 |doi=
*cite journal | author=Xiang M, Zhou L, Peng YW, "et al." |title=Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. |journal=Neuron |volume=11 |issue= 4 |pages= 689–701 |year= 1993 |pmid= 7691107 |doi=
*cite journal | author=Bhargava AK, Li Z, Weissman SM |title=Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 21 |pages= 10260–4 |year= 1993 |pmid= 8234287 |doi=
*cite journal | author=Ring CJ, Latchman DS |title=The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain. |journal=Nucleic Acids Res. |volume=21 |issue= 12 |pages= 2946 |year= 1993 |pmid= 8332509 |doi=
*cite journal | author=Smith MD, Dawson SJ, Latchman DS |title=Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor. |journal=J. Biol. Chem. |volume=272 |issue= 2 |pages= 1382–8 |year= 1997 |pmid= 8995448 |doi=
*cite journal | author=Budhram-Mahadeo V, Parker M, Latchman DS |title=POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 1029–41 |year= 1998 |pmid= 9448000 |doi=
*cite journal | author=Dennis JH, Budhram-Mahadeo V, Latchman DS |title=The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. |journal=Oncogene |volume=20 |issue= 36 |pages= 4961–71 |year= 2001 |pmid= 11526481 |doi= 10.1038/sj.onc.1204491
*cite journal | author=de Melo J, Qiu X, Du G, "et al." |title=Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina. |journal=J. Comp. Neurol. |volume=461 |issue= 2 |pages= 187–204 |year= 2003 |pmid= 12724837 |doi= 10.1002/cne.10674
*cite journal | author=Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS |title=Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor. |journal=Cancer Biol. Ther. |volume=3 |issue= 3 |pages= 317–23 |year= 2004 |pmid= 14726699 |doi=
*cite journal | author=Irshad S, Pedley RB, Anderson J, "et al." |title=The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21617–27 |year= 2004 |pmid= 14970234 |doi= 10.1074/jbc.M312506200
*cite journal | author=Lee SA, Ndisang D, Patel C, "et al." |title=Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter. |journal=Cancer Res. |volume=65 |issue= 8 |pages= 3072–80 |year= 2005 |pmid= 15833836 |doi= 10.1158/0008-5472.CAN-04-2865
*cite journal | author=Weishaupt JH, Klöcker N, Bähr M |title=Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells. |journal=J. Mol. Neurosci. |volume=26 |issue= 1 |pages= 17–25 |year= 2005 |pmid= 15968082 |doi=
*cite journal | author=Samady L, Faulkes DJ, Budhram-Mahadeo V, "et al." |title=The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells. |journal=Int. J. Cancer |volume=118 |issue= 4 |pages= 869–78 |year= 2006 |pmid= 16152597 |doi= 10.1002/ijc.21435
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Choy KW, Wang CC, Ogura A, "et al." |title=Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. |journal=Physiol. Genomics |volume=25 |issue= 1 |pages= 9–15 |year= 2007 |pmid= 16368877 |doi= 10.1152/physiolgenomics.00121.2005
*cite journal | author=Calissano M, Diss JK, Latchman DS |title=Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. |journal=FEBS Lett. |volume=581 |issue= 13 |pages= 2490–6 |year= 2007 |pmid= 17490655 |doi= 10.1016/j.febslet.2007.04.066

External links

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