CAMP responsive element modulator

CAMP responsive element modulator, also known as CREM, is a human gene.cite web | title = Entrez Gene: CREM cAMP responsive element modulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1390| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.cite web | title = Entrez Gene: CREM cAMP responsive element modulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1390| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Don J, Stelzer G |title=The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis. |journal=Mol. Cell. Endocrinol. |volume=187 |issue= 1-2 |pages= 115–24 |year= 2003 |pmid= 11988318 |doi=
*cite journal | author=Yan C, Miller CL, Abe J |title=Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. |journal=Circ. Res. |volume=100 |issue= 4 |pages= 489–501 |year= 2007 |pmid= 17332439 |doi= 10.1161/01.RES.0000258451.44949.d7
*cite journal | author=Meyer TE, Habener JF |title=Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. |journal=Nucleic Acids Res. |volume=20 |issue= 22 |pages= 6106 |year= 1993 |pmid= 1461747 |doi=
*cite journal | author=Pongubala JM, Atchison ML |title=Activating transcription factor 1 and cyclic AMP response element modulator can modulate the activity of the immunoglobulin kappa 3' enhancer. |journal=J. Biol. Chem. |volume=270 |issue= 17 |pages= 10304–13 |year= 1995 |pmid= 7730336 |doi=
*cite journal | author=Walker WH, Sanborn BM, Habener JF |title=An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12423–7 |year= 1995 |pmid= 7809053 |doi=
*cite journal | author=Masquilier D, Foulkes NS, Mattei MG, Sassone-Corsi P |title=Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. |journal=Cell Growth Differ. |volume=4 |issue= 11 |pages= 931–7 |year= 1994 |pmid= 7916662 |doi=
*cite journal | author=Fujimoto T, Fujisawa J, Yoshida M |title=Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. |journal=J. Biochem. |volume=115 |issue= 2 |pages= 298–303 |year= 1994 |pmid= 8206879 |doi=
*cite journal | author=de Groot RP, den Hertog J, Vandenheede JR, "et al." |title=Multiple and cooperative phosphorylation events regulate the CREM activator function. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3903–11 |year= 1993 |pmid= 8404858 |doi=
*cite journal | author=Bodor J, Walker W, Flemington E, "et al." |title=Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM. |journal=FEBS Lett. |volume=377 |issue= 3 |pages= 413–8 |year= 1996 |pmid= 8549766 |doi= 10.1016/0014-5793(95)01299-0
*cite journal | author=Nantel F, Monaco L, Foulkes NS, "et al." |title=Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. |journal=Nature |volume=380 |issue= 6570 |pages= 159–62 |year= 1996 |pmid= 8600390 |doi= 10.1038/380159a0
*cite journal | author=Blendy JA, Kaestner KH, Weinbauer GF, "et al." |title=Severe impairment of spermatogenesis in mice lacking the CREM gene. |journal=Nature |volume=380 |issue= 6570 |pages= 162–5 |year= 1996 |pmid= 8600391 |doi= 10.1038/380162a0
*cite journal | author=Bodor J, Spetz AL, Strominger JL, Habener JF |title=cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3536–41 |year= 1996 |pmid= 8622971 |doi=
*cite journal | author=Gellersen B, Kempf R, Telgmann R |title=Human endometrial stromal cells express novel isoforms of the transcriptional modulator CREM and up-regulate ICER in the course of decidualization. |journal=Mol. Endocrinol. |volume=11 |issue= 1 |pages= 97–113 |year= 1997 |pmid= 8994192 |doi=
*cite journal | author=Laurance ME, Kwok RP, Huang MS, "et al." |title=Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 2646–51 |year= 1997 |pmid= 9006899 |doi=
*cite journal | author=Bonny C, Cooker LA, Goldberg E |title=Deoxyribonucleic acid-protein interactions and expression of the human testis-specific lactate dehydrogenase promoter: transcription factor Sp1 plays a major role. |journal=Biol. Reprod. |volume=58 |issue= 3 |pages= 754–9 |year= 1998 |pmid= 9510963 |doi=
*cite journal | author=Müller FU, Bokník P, Knapp J, "et al." |title=Identification and expression of a novel isoform of cAMP response element modulator in the human heart. |journal=FASEB J. |volume=12 |issue= 12 |pages= 1191–9 |year= 1998 |pmid= 9737722 |doi=
*cite journal | author=Fimia GM, De Cesare D, Sassone-Corsi P |title=CBP-independent activation of CREM and CREB by the LIM-only protein ACT. |journal=Nature |volume=398 |issue= 6723 |pages= 165–9 |year= 1999 |pmid= 10086359 |doi= 10.1038/18237
*cite journal | author=Pati D, Meistrich ML, Plon SE |title=Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5001–13 |year= 1999 |pmid= 10373550 |doi=
*cite journal | author=Inada A, Someya Y, Yamada Y, "et al." |title=The cyclic AMP response element modulator family regulates the insulin gene transcription by interacting with transcription factor IID. |journal=J. Biol. Chem. |volume=274 |issue= 30 |pages= 21095–103 |year= 1999 |pmid= 10409662 |doi=
*cite journal | author=Zauli G, Secchiero P, Rodella L, "et al." |title=HIV-1 Tat-mediated inhibition of the tyrosine hydroxylase gene expression in dopaminergic neuronal cells. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4159–65 |year= 2000 |pmid= 10660577 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes