DBP (gene)

DBP (gene)
D site of albumin promoter (albumin D-box) binding protein
Symbols DBP; DABP
External IDs OMIM124097 MGI94866 HomoloGene1035 GeneCards: DBP Gene
RNA expression pattern
PBB GE DBP 209782 s at tn.png
PBB GE DBP 209783 at tn.png
More reference expression data
Species Human Mouse
Entrez 1628 13170
Ensembl ENSG00000105516 ENSMUSG00000059824
UniProt Q10586 Q3USN7
RefSeq (mRNA) NM_001352 NM_016974.3
RefSeq (protein) NP_001343 NP_058670.2
Location (UCSC) Chr 19:
49.13 – 49.14 Mb
Chr 7:
52.96 – 52.97 Mb
PubMed search [1] [2]

D site of albumin promoter (albumin D-box) binding protein, also known as DBP, is a protein which in humans is encoded by the DBP gene.[1][2]

DBP is a member of the PAR bZIP (Proline and Acidic amino acid-Rich basic leucine ZIPper) transcription factor family.[3][1] DBP binds to a upstream promoter in the insulin gene.[4] Further, it may also regulate the HIF-1, one of the hypoxia inducible factors. [5]


  1. ^ a b "Entrez Gene: DBP D site of albumin promoter (albumin D-box) binding protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1628. 
  2. ^ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293–300. doi:10.1016/0888-7543(92)90245-N. PMID 1535333. http://linkinghub.elsevier.com/retrieve/pii/0888-7543(92)90245-N. 
  3. ^ Khatib ZA, Inaba T, Valentine M, Look AT (September 1994). "Chromosomal localization and cDNA cloning of the human DBP and TEF genes". Genomics 23 (2): 344–51. doi:10.1006/geno.1994.1510. PMID 7835883. 
  4. ^ Melloul D, Marshak S, Cerasi E (March 2002). "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736. 
  5. ^ Sethunarayanan SR (July 2011). "D-site of albumin promoter binding protein (DBP) may regulate hematopoiesis". Biology and Medicine 3 (3): 32–69. http://biolmedonline.com/Articles/Vol3_3_2011/Vol3_3_32-69.pdf. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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