GC (gene)

Group-specific component (vitamin D binding protein), also known as GC, is a human gene.cite web | title = Entrez Gene: GC group-specific component (vitamin D binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2638| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the albumin gene family, together with human serum albumin and alpha-fetoprotein. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues.cite web | title = Entrez Gene: GC group-specific component (vitamin D binding protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2638| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Svasti J, Kurosky A, Bennett A, Bowman BH |title=Molecular basis for the three major forms of human serum vitamin D binding protein (group-specific component). |journal=Biochemistry |volume=18 |issue= 8 |pages= 1611–7 |year= 1979 |pmid= 218624 |doi=
*cite journal | author=Mikkelsen M, Jacobsen P, Henningsen K |title=Possible localization of Gc-System on chromosome 4. Loss of long arm 4 material associated with father-child incompatibility within the Gc-System. |journal=Hum. Hered. |volume=27 |issue= 2 |pages= 105–7 |year= 1977 |pmid= 558959 |doi=
*cite journal | author=Braun A, Bichlmaier R, Cleve H |title=Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types. |journal=Hum. Genet. |volume=89 |issue= 4 |pages= 401–6 |year= 1992 |pmid= 1352271 |doi=
*cite journal | author=Esteban C, Geuskens M, Ena JM, "et al." |title=Receptor-mediated uptake and processing of vitamin D-binding protein in human B-lymphoid cells. |journal=J. Biol. Chem. |volume=267 |issue= 14 |pages= 10177–83 |year= 1992 |pmid= 1374401 |doi=
*cite journal | author=Szpirer C, Riviere M, Cortese R, "et al." |title=Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). |journal=Genomics |volume=13 |issue= 2 |pages= 293–300 |year= 1992 |pmid= 1535333 |doi=
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Yang F, Bergeron JM, Linehan LA, "et al." |title=Mapping and conservation of the group-specific component gene in mouse. |journal=Genomics |volume=7 |issue= 4 |pages= 509–16 |year= 1990 |pmid= 1696927 |doi=
*cite journal | author=Yang F, Luna VJ, McAnelly RD, "et al." |title=Evolutionary and structural relationships among the group-specific component, albumin and alpha-fetoprotein. |journal=Nucleic Acids Res. |volume=13 |issue= 22 |pages= 8007–17 |year= 1986 |pmid= 2415926 |doi=
*cite journal | author=Yang F, Brune JL, Naylor SL, "et al." |title=Human group-specific component (Gc) is a member of the albumin family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 23 |pages= 7994–8 |year= 1986 |pmid= 2415977 |doi=
*cite journal | author=Cooke NE, David EV |title=Serum vitamin D-binding protein is a third member of the albumin and alpha fetoprotein gene family. |journal=J. Clin. Invest. |volume=76 |issue= 6 |pages= 2420–4 |year= 1986 |pmid= 2416779 |doi=
*cite journal | author=Schoentgen F, Metz-Boutigue MH, Jollès J, "et al." |title=Complete amino acid sequence of human vitamin D-binding protein (group-specific component): evidence of a three-fold internal homology as in serum albumin and alpha-fetoprotein. |journal=Biochim. Biophys. Acta |volume=871 |issue= 2 |pages= 189–98 |year= 1986 |pmid= 2423133 |doi=
*cite journal | author=McNearney TA, Odell C, Holers VM, "et al." |title=Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement-mediated neutralization of viral infectivity. |journal=J. Exp. Med. |volume=166 |issue= 5 |pages= 1525–35 |year= 1987 |pmid= 2824652 |doi=
*cite journal | author=Yang F, Naberhaus KH, Adrian GS, "et al." |title=The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals. |journal=Gene |volume=54 |issue= 2-3 |pages= 285–90 |year= 1987 |pmid= 2958390 |doi=
*cite journal | author=Cooke NE, Willard HF, David EV, George DL |title=Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism. |journal=Hum. Genet. |volume=73 |issue= 3 |pages= 225–9 |year= 1986 |pmid= 3015768 |doi=
*cite journal | author=Nestler JE, McLeod JF, Kowalski MA, "et al." |title=Detection of vitamin D binding protein on the surface of cytotrophoblasts isolated from human placentae. |journal=Endocrinology |volume=120 |issue= 5 |pages= 1996–2002 |year= 1987 |pmid= 3552627 |doi=
*cite journal | author=Pierce EA, Dame MC, Bouillon R, "et al." |title=Monoclonal antibodies to human vitamin D-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=82 |issue= 24 |pages= 8429–33 |year= 1986 |pmid= 3936035 |doi=
*cite journal | author=Wooten MW, Nel AE, Goldschmidt-Clermont PJ, "et al." |title=Identification of a major endogenous substrate for phospholipid/Ca2+-dependent kinase in pancreatic acini as Gc (vitamin D-binding protein). |journal=FEBS Lett. |volume=191 |issue= 1 |pages= 97–101 |year= 1985 |pmid= 4054306 |doi=
*cite journal | author=Constans J, Oksman F, Viau M |title=Binding of the apo and holo forms of the serum vitamin D-binding protein to human lymphocyte cytoplasm and membrane by indirect immunofluorescence. |journal=Immunol. Lett. |volume=3 |issue= 3 |pages= 159–62 |year= 1981 |pmid= 7026425 |doi=
*cite journal | author=Braun A, Kofler A, Morawietz S, Cleve H |title=Sequence and organization of the human vitamin D-binding protein gene. |journal=Biochim. Biophys. Acta |volume=1216 |issue= 3 |pages= 385–94 |year= 1994 |pmid= 7505619 |doi=
*cite journal | author=Swamy N, Roy A, Chang R, "et al." |title=Affinity purification of human plasma vitamin D-binding protein. |journal=Protein Expr. Purif. |volume=6 |issue= 2 |pages= 185–8 |year= 1995 |pmid= 7606167 |doi= 10.1006/prep.1995.1023

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