NFE2

Nuclear factor (erythroid-derived 2), 45kDa
Rendering based on PDB 1LVX.
Available structures PDB 1LVX, 2KZ5
Identifiers
Symbols	NFE2; NF-E2; p45
External IDs	OMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCards: NFE2 Gene
Gene Ontology Molecular function • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • sequence-specific DNA binding • protein dimerization activity • protein N-terminus binding • WW domain binding • WW domain binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • actin cytoskeleton • PML body Biological process • nucleosome disassembly • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • multicellular organismal development • blood coagulation • hemostasis • blood circulation • positive regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4778	18022
Ensembl	ENSG00000123405	ENSMUSG00000058794
UniProt	Q16621	n/a
RefSeq (mRNA)	NM_001136023.1	NM_008685.2
RefSeq (protein)	NP_001129495.1	NP_032711.2
Location (UCSC)	Chr 12: 54.69 – 54.69 Mb	Chr 15: 103.08 – 103.09 Mb
PubMed search	[1]	[2]

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.^[1][2]

Interactions

NFE2 has been shown to interact with CREB-binding protein.^[3]

References

1. ^ Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol 13 (9): 5604–12. PMC 360284. PMID 8355703. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360284. 
2. ^ "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4778. 
3. ^ Hung, H L; Kim A Y, Hong W, Rakowski C, Blobel G A (Apr. 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. (United States) 276 (14): 10715–21. doi:10.1074/jbc.M007846200. ISSN 0021-9258. PMID 11154691. 

Further reading

• Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.". Mol. Cell. Biol. 12 (5): 2135–42. PMC 364385. PMID 1569944. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=364385. 
• Pischedda C; Cocco S; Melis A et al. (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. doi:10.1073/pnas.92.8.3511. PMC 42197. PMID 7724591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42197. 
• Shivdasani RA; Rosenblatt MF; Zucker-Franklin D et al. (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development". Cell 81 (5): 695–704. doi:10.1016/0092-8674(95)90531-6. PMID 7774011. 
• Igarashi K; Kataoka K; Itoh K et al. (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature 367 (6463): 568–72. doi:10.1038/367568a0. PMID 8107826. 
• Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. doi:10.1073/pnas.90.23.11366. PMC 47983. PMID 8248255. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=47983. 
• Toki T; Itoh J; Kitazawa J et al. (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357. 
• Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood 89 (11): 3925–35. PMID 9166829. 
• Gavva NR; Gavva R; Ermekova K et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852. 
• Mosser EA; Kasanov JD; Forsberg EC et al. (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456. 
• Hung HL; Kim AY; Hong W et al. (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691. 
• Gavva NR; Wen SC; Daftari P et al. (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372. 
• Boulanger L; Sabatino DE; Wong EY et al. (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Marini MG; Asunis I; Chan K et al. (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145–58. doi:10.1006/bcmd.2002.0550. PMID 12490281. 
• Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425. 
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554. 
• Chuen CK; Li K; Yang M et al. (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

External links

• MeSH NFE2+protein,+human
• FactorBook NF-E2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.