MAFF (gene)

MAFF (gene)

V-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian), also known as MAFF, is a human gene.cite web | title = Entrez Gene: MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)| url =| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Two transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: MAFF v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)| url =| accessdate = ]

ee also

* MAF (gene)


Further reading

citations =
*cite journal | author=Ye X, Li Y, Huang Q, "et al." |title=The novel human gene MIP functions as a co-activator of hMafF. |journal=Arch. Biochem. Biophys. |volume=449 |issue= 1-2 |pages= 87–93 |year= 2006 |pmid= 16549056 |doi= 10.1016/
*cite journal | author=Massrieh W, Derjuga A, Doualla-Bell F, "et al." |title=Regulation of the MAFF transcription factor by proinflammatory cytokines in myometrial cells. |journal=Biol. Reprod. |volume=74 |issue= 4 |pages= 699–705 |year= 2006 |pmid= 16371591 |doi= 10.1095/biolreprod.105.045450
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Marini MG, Asunis I, Chan K, "et al." |title=Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation. |journal=Blood Cells Mol. Dis. |volume=29 |issue= 2 |pages= 145–58 |year= 2003 |pmid= 12490281 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moran JA, Dahl EL, Mulcahy RT |title=Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators. |journal=Biochem. J. |volume=361 |issue= Pt 2 |pages= 371–7 |year= 2002 |pmid= 11772409 |doi=
*cite journal | author=Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M |title=A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities. |journal=J. Biol. Chem. |volume=276 |issue= 1 |pages= 819–26 |year= 2001 |pmid= 11036080 |doi= 10.1074/jbc.M007643200
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Kimura T, Ivell R, Rust W, "et al." |title=Molecular cloning of a human MafF homologue, which specifically binds to the oxytocin receptor gene in term myometrium. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 86–92 |year= 1999 |pmid= 10527846 |doi= 10.1006/bbrc.1999.1487
*cite journal | author=Johnsen O, Skammelsrud N, Luna L, "et al." |title=Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. |journal=Nucleic Acids Res. |volume=24 |issue= 21 |pages= 4289–97 |year= 1996 |pmid= 8932385 |doi=
*cite journal | author=Igarashi K, Kataoka K, Itoh K, "et al." |title=Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins. |journal=Nature |volume=367 |issue= 6463 |pages= 568–72 |year= 1994 |pmid= 8107826 |doi= 10.1038/367568a0

External links


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