IKZF3

IKAROS family zinc finger 3 (Aiolos), also known as IKZF3, is a human gene.cite web | title = Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.cite web | title = Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schmitt C, Tonnelle C, Dalloul A, "et al." |title=Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation. |journal=Apoptosis |volume=7 |issue= 3 |pages= 277–84 |year= 2003 |pmid= 11997672 |doi=
*cite journal | author=Morgan B, Sun L, Avitahl N, "et al." |title=Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. |journal=EMBO J. |volume=16 |issue= 8 |pages= 2004–13 |year= 1997 |pmid= 9155026 |doi= 10.1093/emboj/16.8.2004
*cite journal | author=Wang JH, Avitahl N, Cariappa A, "et al." |title=Aiolos regulates B cell activation and maturation to effector state. |journal=Immunity |volume=9 |issue= 4 |pages= 543–53 |year= 1998 |pmid= 9806640 |doi=
*cite journal | author=Kim J, Sif S, Jones B, "et al." |title=Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. |journal=Immunity |volume=10 |issue= 3 |pages= 345–55 |year= 1999 |pmid= 10204490 |doi=
*cite journal | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090–100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090
*cite journal | author=Romero F, Martínez-A C, Camonis J, Rebollo A |title=Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. |journal=EMBO J. |volume=18 |issue= 12 |pages= 3419–30 |year= 1999 |pmid= 10369681 |doi= 10.1093/emboj/18.12.3419
*cite journal | author=Hosokawa Y, Maeda Y, Takahashi E, "et al." |title=Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. |journal=Genomics |volume=61 |issue= 3 |pages= 326–9 |year= 2000 |pmid= 10552935 |doi= 10.1006/geno.1999.5949
*cite journal | author=Koipally J, Georgopoulos K |title=Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity. |journal=J. Biol. Chem. |volume=275 |issue= 26 |pages= 19594–602 |year= 2000 |pmid= 10766745 |doi= 10.1074/jbc.M000254200
*cite journal | author=Perdomo J, Holmes M, Chong B, Crossley M |title=Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. |journal=J. Biol. Chem. |volume=275 |issue= 49 |pages= 38347–54 |year= 2001 |pmid= 10978333 |doi= 10.1074/jbc.M005457200
*cite journal | author=Rebollo A, Ayllón V, Fleischer A, "et al." |title=The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis. |journal=J. Immunol. |volume=167 |issue= 11 |pages= 6366–73 |year= 2002 |pmid= 11714801 |doi=
*cite journal | author=Liippo J, Nera KP, Veistinen E, "et al." |title=Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. |journal=Eur. J. Immunol. |volume=31 |issue= 12 |pages= 3469–74 |year= 2002 |pmid= 11745366 |doi=
*cite journal | author=Nakase K, Ishimaru F, Fujii K, "et al." |title=Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia. |journal=Exp. Hematol. |volume=30 |issue= 4 |pages= 313–7 |year= 2002 |pmid= 11937265 |doi=
*cite journal | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697–705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Antica M, Dubravcic K, Weber I, "et al." |title=A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia. |journal=Haematologica |volume=92 |issue= 2 |pages= 260–1 |year= 2007 |pmid= 17296582 |doi=
*cite journal | author=Ghadiri A, Duhamel M, Fleischer A, "et al." |title=Critical function of Ikaros in controlling Aiolos gene expression. |journal=FEBS Lett. |volume=581 |issue= 8 |pages= 1605–16 |year= 2007 |pmid= 17383641 |doi= 10.1016/j.febslet.2007.03.025
*cite journal | author=Caballero R, Setien F, Lopez-Serra L, "et al." |title=Combinatorial effects of splice variants modulate function of Aiolos. |journal=J. Cell. Sci. |volume=120 |issue= Pt 15 |pages= 2619–30 |year= 2007 |pmid= 17646674 |doi= 10.1242/jcs.007344

External links

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