HIF3A

Hypoxia inducible factor 3, alpha subunit, also known as HIF3A, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.cite web | title = Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64344| accessdate = ]

ee also

* Hypoxia inducible factors

References

Further reading

*cite journal | author=Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA. |title=Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. |journal=Gene Expr. |volume=7 |issue= 3 |pages= 205–13 |year= 1998 |pmid= 9840812PBB_Further_reading
citations =
*cite journal | author=Hara S, Hamada J, Kobayashi C, "et al." |title=Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. |journal=Biochem. Biophys. Res. Commun. |volume=287 |issue= 4 |pages= 808–13 |year= 2001 |pmid= 11573933 |doi= 10.1006/bbrc.2001.5659
*cite journal | author=Makino Y, Cao R, Svensson K, "et al." |title=Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. |journal=Nature |volume=414 |issue= 6863 |pages= 550–4 |year= 2002 |pmid= 11734856 |doi= 10.1038/35107085
*cite journal | author=Makino Y, Kanopka A, Wilson WJ, "et al." |title=Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 32405–8 |year= 2002 |pmid= 12119283 |doi= 10.1074/jbc.C200328200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Maynard MA, Qi H, Chung J, "et al." |title=Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11032–40 |year= 2003 |pmid= 12538644 |doi= 10.1074/jbc.M208681200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Maynard MA, Evans AJ, Hosomi T, "et al." |title=Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. |journal=FASEB J. |volume=19 |issue= 11 |pages= 1396–406 |year= 2006 |pmid= 16126907 |doi= 10.1096/fj.05-3788com
*cite journal | author=Jang MS, Park JE, Lee JA, "et al." |title=Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 1 |pages= 209–15 |year= 2005 |pmid= 16182248 |doi= 10.1016/j.bbrc.2005.09.038
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Li QF, Wang XR, Yang YW, Lin H |title=Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha. |journal=Cell Res. |volume=16 |issue= 6 |pages= 548–58 |year= 2006 |pmid= 16775626 |doi= 10.1038/sj.cr.7310072
*cite journal | author=Kollers S, Musilova P, Rubes J, Rocha D |title=Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13. |journal=Anim. Genet. |volume=37 |issue= 6 |pages= 595–6 |year= 2007 |pmid= 17121608 |doi= 10.1111/j.1365-2052.2006.01516.x

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